Evaluation of nephroprotective activity ethanolic extract of stem bark extract of Tephrosia purpurea
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 3
Abstract
Objective: To evaluate the nephroprotective activity of Ethanolic extract of Tephrosia purpurea (T.purpurea) (Fabaceae) in Gentamycin and Cisplatin-induced acute renal failure in rats. Materials and Methods: Tephrosia purpurea (200 mg/kg and 400 mg/kg body weight), were administered orally to male Wistar albino rats in Gentamycin(GT) and Cisplatin(CP) was used to induce acute renal failure. The parameters studied included blood urea and serum creatinine and antioxidant parameters like malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) enzymes Results: The results revealed that Tephrosia purpurea pretreatment signiûcantly reduced blood urea and serum creatinine levels elevated by CP administration. Furthermore, Tephrosia purpurea significantly attenuated GT and CP-induced increase in MDA and decrease in reduced GSH, and CAT and SOD activities in renal cortical homogenates and it was showed that Tephrosia purpurea markedly ameliorated GT and CP-induced renal tubular necrosis. Conclusion: The results indicate that the stem bark Tephrosia purpurea endowed with nephroprotective activity.
Authors and Affiliations
N. S. Murali Krishna, K. Appanna Chowdary
Keywords
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