Evaluation of Pedilanthus Tithymaloides Ethanolic Leaf Extract on Serum Lipid Profile Changes in Normal and Alloxan Induced Diabetic Albino Wistar Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 1
Abstract
Type 1diabetes is associated with damage to the liver, kidney and pancreas of patients. The damage varies in proportion and susceptibility among diabetic patients of type 1 class. This study assessed the hypoglycaemic and antihyperlipidemic activities of whole ethanolic leaf extract of Pedilanthus tithymaloides in alloxan-induced diabetic albino Wistar rats. Extraction of the ethanolic extract of Pedilanthus tithymaloides was performed by maceration. Thirty rats were divided into five groups. Group I consists of normal rats that were given only normal saline solution and served as a control group. Group II consists of normal rats that were given alloxan monohydrate (150mg/kg B.W). Group III consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (500 mg/kg), Group IV consists of alloxan induced diabetic rats that were given daily sterile solution, ethanolic leaf extract of Pedilanthus tithymaloides (1000 mg/kg), Group V consists of alloxan induced diabetic rats that were given daily sterile solution and glibenclamide(5mg/kg) respectively for 21 days by an instragastric tube with free access of food and water. Several biochemical parameters were assessed. Oral administration of the extract resulted in significant reduction in mean values of blood glucose, cholesterol, triglycerides, LDL-C, VLDL accompanied by an increase in the mean values of the HDL in diabetic rats. The effects produced by this extract were closely similar to a standard anti diabetic drug, glibenclamide. In conclusion, the present study indicates that the ethanolic extract of Pedilanthus tithymaloides to exhibit antihyperlipidemic and antihyperglycemic activities in alloxan induced diabetic rats.
Authors and Affiliations
Mehnoor Farheen1, Chakrapani Rmesh2
Keywords
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- EP ID EP383233
- DOI 10.9790/3008-11110118
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