Evaluation of Role of Tinospora Cordifolia (T.cord.) In Experimentally Induced (Busulfan Induced) Thrombocytopenia In Rabbits
Journal Title: PARIPEX-Indian Journal of Research - Year 2016, Vol 5, Issue 6
Abstract
Introduction:Tinosporacordifolia has been used in the indigenous system of medicine since the Vedic period and considered as one of the best drugs in terms of availability, economy and ease of administration. Aim & objective: To evaluate the role of tinosporacordifolia in experimentally induced thrombocytopenia in rabbits. Materials &methods: The study was conducted in conscious albino rabbits of either sex weighing 1.5-2.5kg, divided into 7 groups with 6 rabbits in each. Platelet counts before drug administration served as its own control. Group 1 was given normal saline 5ml/kg P/O, group 2 busulfan 50mg/ kg P/O in a single dose once only, group 3 aq. ext. of T. Cord. 4ml/kg P/Oand group 4 & 5 were given aq. ext. of T. Cord. 2ml/kg & 4ml/kg respectively started on 14th day (after attaining maximum thrombocytopenia by busulfan). Blood was withdrawn on day 1 and then weekly i.e. on 7th, 14th, 21st, 28th, 35th & 42nd days of study for the study of platelet counts by preparing peripheral blood smear. Results- Gr. IV & V showed a significant improvement in platelet counts. This beneficial effect of aq. ext. of T. Cord. suggests that it probably acts by improving the production of platelets from bone marrow due to its antioxidant and immunomodulatory properties. This beneficial role of T. Cord. can be attributed to the presence of various phytochemical constituents like alkaloids, sesquiterpenoid and glycosides present in the stem. Conclusion: Thus it was concluded from our study that the aqueous extract possessestherapeutic role in thrombocytopenia.
Authors and Affiliations
Chauhan D. S, Lata S, Sharma R. K, Jindal M, Gupta A. K, Suman A, Rehman S, Malik P
Keywords
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