Evaluation of the Anticonvulsant Effect of the Methanol Extract of Evolvulus alsinoides in Mice
Journal Title: Scholars Academic Journal of Pharmacy - Year 2013, Vol 2, Issue 6
Abstract
The purpose of this research work is to study the anticonvulsant activity of Evolvulus aisinoides Linn (convolvulacea) used in traditional medicine for the treatment of neurodegenerative diseases, amnesia, mental illness and epilepsy. In this study, the anticonvulsant activity of the crude methanolic extract was investigated at doses of 50, 100, 200 and 400 mg/kg using the Pentylenetetrazole (PTZ) induced seizure (chemically induced seizure) and maximal electroshock seizure (electrically induced seizure) models in mice. The sedative hypnotic effect was also studied using the Diazepam induce sleep model. The onset of diazepam induced sleep was decreased dose dependently; there was a marked increase in duration of sleep to 4-7 times the duration of sleep in the control group.. The extract at doses of 100-400 significantly increased the latency of PTZ induced seizure; there was a 100% protection against seizure at the highest dose of 400mg/kg. In the MEST test a dose dependent decrease in the duration of seizure was also observed with all the doses administered.400mg/kg of the extract and 30mg/kg Diazepam shows the highest activity in this test. These findings suggest that the methanol extract of the plant contains bioactive principles that may be beneficial in the treatment of epilepsy. Keywords: Diazepam, epilepsy,seizure, Evolvulus alsinoides, methanol, pentylenetetrazole.
Authors and Affiliations
Abubakar K, Ugwah- Oguejiofor C. J, Usman M. N. , Abubakar S. B, Abdulkadir R
Keywords
Related Articles
- EP ID EP378470
- DOI -
- Views 101
- Downloads 0
A Pharmacognostic and pharmacological overview on Bombax ceiba
Bombax ceiba is commonly known as silk cotton tree and semal which belongs to family Bombacaceae. Bombax ceiba is an important medicinal plant of tropical and subtropical India. Its medicinal usage has been reported in t...
Assessment of Serum Lipid Profile among Sudanese Patients with Malaria
Changes in lipid profile are seen in many patients infected with malaria parasite. The malaria parasite causes hepatocellular damage and disturbs lipid handling by the liver. Inside hepatocytes and erythrocytes the paras...
Vitamin D Administration: Intramuscular versus oral route: Comparisonof Effectiveness
Vitamin D is afat soluble vitamin essential for bone health. Its deficiency is highly prevalent all over the world without adequate steps or efforts to solve this problem.The aim of the study is to compare the effectiven...
In-Vitro Antioxidant Potential of Delonix regia Leaves
Antioxidants are an inhibitor of the process of oxidation, even at relatively small concentration and thus have diverse physiological role in the body. The present study was carried out to identify the phytochemicals and...
Evaluation In-Vitro Antioxidant, Antimicrobial and Laxative Potential of Ethanol Leaves Extract of Synedrellanodiflora (L) Gaertn on Wistar Albino Rats
Synedrellanodiflora (L) Gaertn, commonly known as Pig grass, Cinderella weed, node weed is a species of flowering plant in the family of Asteraceae. It is a medicinal plant mostly used in the herbal medicine to cure lepr...