EVALUATION OF THE EFFECTS OF Gutenbergia nigritana LEAVES EXTRACT ON CEREBELLUM OF ADULT MICE AND ITS IMPLICATION ON MANGANESE TOXICITY
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 3
Abstract
Manganese is an important trace element in the biological system and its excessive exposure may lead to a neurological disorder known as manganism. Hence, checking the ameliorative effects of Gutenbergia nigritana leaves extract on the neuronal integrity of the cerebellum in motor deficit is of keen interest. Fifty adult male mice weighing between 25-35g were divided randomly into 5 groups. Manganese administration was for 7 days intraperitoneally at the dose of 40mg/kg body weight while G. nigratana extract was for 14 days and administered orally. Motor coordination was assessed in the animals using rotarod and parallel bar test. Animals sacrifice was done by humane killing followed by transcardiac perfusion fixation, the region of cerebellum were dissected out and fixed in 10% formal calcium for 72 hours, then processed for H&E stains for neuroarchitecture. Behaviourally, manganese treated group shows decreased motor activity on the rotarod, increased time of turn and time to edge during parallel bar test was noticed. Mncl2 altered the integrity of purkinje neurons with appearance of indistinct cell bodies and scantily distributed granular cells. Manganese toxicity induces motor deficit from neurodegeneration but Gutenbergia nigritana extract revealed some ameliorative effect on the cells of the Cerebellar cortex.
Authors and Affiliations
Adekeye Adeshina Oloruntoba
Keywords
Related Articles
- EP ID EP621239
- DOI -
- Views 126
- Downloads 0
CHRONIC MYELOID LEUKEMIA PATIENT WITH ISOLATED CENTRAL NERVOUS SYSTEM BLAST CRISIS
The first therapeutic choice in Chronic Myeloid Leukemia (CML) is imatinib mesylate, a potent inhibitor of BCR / ABL tyrosine kinase. The blood brain barrier is poorly penetrated so that therapeutic concentrations in the...
RELATIONSHIP BETWEEN BREASTFEEDING DURATION AND ACUTE RESPIRATORY INFECTIONS IN INFANTS: A CROSS SECTIONAL STUDY IN THE CHILD CENTRAL TEACHING HOSPITAL
Background: Human milk is the ideal and uniquely superior food for infants for the first year of life and as the sole source of nutrition for the first six months. Breast l'eeding is beneficial for both babies and mother...
ADVANCE OF PHOTODYNAMIC THERAPY IN THE TREATMENT OF NON-MELANOMA SKIN CANCER: LITERATURE REVISION
Non-melanoma skin cancer is the cancer with the highest incidence in Brazil, corresponding to 30% of all malignancies registered in the country. This type of neoplasm has low lethality, but delayed diagnosis can lead to...
A REVIEW ON TECHNIQUES TO IMPROVE SOLUBILITY OF POORLY SOLUBLE DRUGS
Solubility is the phenomenon in which the conversion of solute into solution, and it is very important for the absorption, bioavailability and pharmacological response. About 40% new drug has water solubility, which is d...
CONCEPTUAL STUDY OF BHRAJAK PITTA W.S.R. TO SHVITRA
Ayurveda is an ancient health science which helps in the eradication of disease as well as maintaining health of healthy person.It forms a precious base of Indian culture. It is best among all the health sciences because...