Evaluation of the Haemostatic Activities of Sida corymbosa in Rats
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 5, Issue 6
Abstract
Aims: To evaluate the anti-haemorrhagic activity of the leaf extract of Sida corymbosa in Wistar albino rats, a plant used to arrest bleeding in ethnomedical practices. Methods: The acute toxicity test was carried out in rats. The haemostatic activities of the extract were investigated using the tail bleeding time and amount of bleeding in rats; effects on haematological parameters were also evaluated in Wistar rats. Preliminary phytochemical analysis was conducted to detect the phytoconstituents of the extract of Sida corymbosa. Results: In this study, the oral LD50 of the extract was found to be greater than 5 g/kg. Administration of the extract to rats for 14 days produced a dose-dependent and significant (P≤0.05) decrease in bleeding time and quantity of blood loss in pre-treated rats. On oral administration of the extract, the effects of the treatment on haematological parameters – White blood cells, Red blood cell, haemoglobin concentration were not significantly different from control. Conclusion: This study has shown that Sida corymbosa has constituents with anti-haemorrhagic properties in rats thereby providing scientific validation for the ethnomedical use of the plant in bleeding control.
Authors and Affiliations
Lucy B. John-Africa, Mercy Aboh
Keywords
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- EP ID EP344464
- DOI 10.9734/BJPR/2015/15676
- Views 101
- Downloads 0
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