Evaluation of the relationship between nitric oxide level and severity of Plasmodium falciparum malaria
Journal Title: Medpulse International Journal of Physiology - Year 2017, Vol 3, Issue 1
Abstract
Background: According to WHO’s estimated number of cases, India has the largest number of malaria cases occurring outside of Africa. Karnataka has the highest incidence of malaria in south India and in 2015 nearly 100 thousand cases were reported in this state, with 22 deaths. Malaria is a significant and serious health problem in Karnataka state and particularly in Dakshina Kannada (Mangalore) district. Methods: Blood samples were collected from both controls and patients for a series of laboratory investigations using standard protocols for estimation of hematological profile, nitrite / nitrate levels. Results: Significant decrease in hemoglobin level and thrombocytopenia were the two most important hematological abnormalities seen in our cases of acute malaria infection. The chances of anemia was related more to decrease in hemoglobin level, while, thrombocytopenia was associated with P. falciparum infection. Conclusion: All together, these results point out to the fact that nitric oxide is in fact a marker of clinical infections can be used as an indicator for the severity of the disease.
Authors and Affiliations
Shreyas Samaga, Shrikant L Patil
Keywords
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