EVALUATION OF THREE CASES WITH ACUTE CORONARY SYNDROME CAUSED BY CORONARY THROMBUS
Journal Title: Kocatepe Medical Journal - Year 2021, Vol 6, Issue 22
Abstract
Coronary thrombus causes reduced blood flow in patients with acute myocardial infarction. Our aim was to to contribute to the understanding of the mechanisms of coronary occlusion caused by thrombus, evaluating the histopathological characteristics of thrombi in three cases. Cases were diagnosed with ST elevation type of myocardial infarction by coronary angiography. Histopathological analysis of thrombi as well as immunohistochemical staining with PTX3 (pentraxin 3, an acute phase protein) and CD68 (a cytokine released from monocyte and macrophages) were performed. Blood levels of troponin and PTX3 were also evaluated. The PTX3 immunostaining score was high in all cases but it was not consistent with its blood level. The high PTX3 staining intensity in the case with normal PTX3 blood level may be the result of rapid local release of PTX3. Case with highest PTX3 blood level had another inflammatory disease that could have driven this increase. We suggest that PTX3 and CD68 immunostainings can be used as a marker in the histopathological evaluation of coronary thrombus.
Authors and Affiliations
Aysel GÜVEN BAĞLA, Meltem İÇKİN GÜLEN, Bahadır KIRILMAZ, Ertuğrul ERCAN
Keywords
Related Articles
- EP ID EP697206
- DOI https://doi.org/10.18229/kocatepetip.571532
- Views 82
- Downloads 0
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