Evaluation of Total Oxidative Stress, Total Antioxidant Capacity Along with Selenium and Vitamin E Level among Saudi Women Experiencing Unexplained Recurrent Miscarriage and Intrauterine Foetal Death
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
Introduction: Oxidative stress is integrated with declined female fertility. Our modern sedentary life style and exposure to toxins make vulnerable to body to increased amount of oxidative stress and lead to higher oxidative damage to DNA and may affect ova, sperm or the development of the embryo, leading to infertility, miscarriage and congenital defects. In the present study our aim was to assess the concentration of total oxidative stress, total antioxidant capacity, selenium and vitamin E level in women suffering from recurrent spontaneous miscarriage and intra uterine foetal death and compare levels with normal pregnant women. Methods: In this cross-sectional study, a group of pregnant women (n= 82) at less than 10 weeks of gestation and a control group of healthy pregnancies with similar characteristics (n=85) were included.. Serum total antioxidant capacity and total oxidant status level were determined using Hitachi 912 analyzer whereas selenium level was measured fluorometrically and vitamin E level was determined by using HPLC. Results: As compared with the control group, the Mean± SD value of maternal serum TOS level was significantly higher in study group patients (4.29 ± 0.67vs. 2.46 ± 0.52mmol Trolox Equiv./L; p< 0.001) whereas TAC value was recorded significantly lower (1.03 ± 0.22vs.1.86 ± 0.10mmol Trolox Equiv./L; p < 0.05). Vitamin E level and selenium level was significantly low statistically in study group patients (4.86 ± 0.21 vs. 9.23 ± 0.26 mg/l; (p<0.001) and (76.66 ± 1.63vs. 95.67 ± 1.83 ng/ml; (p<0.001) respectively at the level of 1%. The mean ± SD value of TOS, TAC, vitamin E and Selenium in two different sub categories of study group shows no any statistical significant difference for all included parameters. Conclusion: Increased total oxidative stress and low TAC level along with low level of vitamin E and selenium might be a significant reason of recurrent miscarriage.
Authors and Affiliations
Poonam Tyagi, Noura Al- Dayan, Abeer Ali El Sherbiny Ateya
Keywords
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- EP ID EP536938
- DOI 10.21276/ijmrp.2018.4.5.035
- Views 73
- Downloads 0
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