Evaluation of various parameters in tuberculous meningitis
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 1
Abstract
Introduction: Meningitis still remains a condition of significance mortality and morbidity in pediatric practice. Tubercular and bacterial meningitis form an important group of neurological diseases associated with considerable mortality and morbidity in children. Tuberculous meningitis is the most serious complication of Mycobacterium tuberculosis infection. In children, at the time of primary infection, leptomeninges might get seeded and they may develop this disease subsequently. Aims and Objectives: To Evaluate Various Parameters in Tuberculous Meningitis Methodology: The present study was carried out in the Department of Biochemistry at Government Medical College and Hospital, Aurangabad during the period June 1999 to June 2001. The study was carried out on 8 patients of tubercular meningitis and 20 controls from pediatric age group. The diagnosis of meningitis was made on clinical findings, microscopic examination of CSF, biochemical examination of CSF, culture studies and radiological studies. Estimation of Blood Glucose done by Trinders methods. Estimation of CSF total proteins by turbidometric method (Meulemans I960):- (Wooten I.D.P., 1964). Colorimetric Method used for Estimation of CSF Lactate Dehydrogenase (LDH): (Wooten I.D.P., 1964). Estimation of CSF GOT and CSF GPT( Reitman and Frankel, 1957; Wooten I.D.P., 1964)were done in Laboratory. Unpaired t –test was used to see statistical significance. Result: The decrease in mean CSF Sugar value in group in Controls and Tuberculousmeningitis is statistically significant (P<0.05). Decrease in mean CSF Sugar /blood sugar ratio in Controls and Tuberculousmeningitisis statistically significant (P<0.05). Increase in mean CSF protein value inControls and Tuberculousmeningitis is statistically significant (P<0.05). The increase in mean CSF GOT value inControls and Tuberculous meningitis. The increase is statistically significant (P<0.05). The increase in mean CSF GPT value in Controls and Tuberculousmeningitisis statistically significant (P<0.05). Conclusion: Thus we have concluded that CSF GOT, GPT and LDH help the clinician for diagnosing Tuberculous meningitis in addition to the routine investigations.
Authors and Affiliations
Kavindra Borgaonkar, Ranjit Patil
Keywords
Related Articles
- EP ID EP198815
- DOI -
- Views 81
- Downloads 0
Safe administration of chemotherapy by laminar hood
Chemotherapy can be life saving to a cancer patient, but unintentional exposure to these powerful agents may be endangering the lives of healthcare workers. Cytotoxic agents can be administered in a variety of ways. Prec...
Association of higher circulatory levels of homocysteine with additional risk factors in CAD patients
Introduction: Coronary artery disease (CAD) is a leading cause of mortality worldwide. In developing countries it has been observed that stressful life style is mainly associated with CAD. Inflammatory environment has be...
The study of wound healing potential of Ropan tail in rats
The present study was undertaken to study wound healing potential of Ropan tail. 12 male wistar rats were taken, divided in two groups, 6 rats per group Control (Normal saline) and Ropan tail. The nape of neck was shaved...
Clinico–mycological profiles of dermatophytoses associated with patients of tinea corporis in a tertiary care hospital
Background: Tinea corporis affecting glabrous skin of the trunk and limbs is the commonest clinical form of dermatophytoses. Clinical lesions caused by the dermatophyte causing agents arehighly variable and closely resem...
Clinicopathologic study of pediatric neoplasm
Objective: Paediatric malignancies, being a significant cause of death among children. This study was performed with an aim to find out the profile of childhood cancers in rural tertiary care hospital, for a period of si...