Evaluation of Vitamin D levels in Metabolic syndrome and its correlation with glycemic profile and cardiovascular risk factors
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 7
Abstract
Aims: Evaluation of Vitamin D levels in people with metabolic syndrome and to evaluate the relationship between Vitamin D and traditional Cardiovascular disease risk factors [blood pressure, FBS/PPBS, obesity, dyslipidemia, hsCRP. Settings and Design: Observational cross-sectional study. Methods and Material: Study was conducted in the Department of Medicine, MLN Medical College and SRN Hospital, Allahabad. Individuals aged ≥18 years and ≤65 years of either sex with metabolic syndrome were taken as cases and healthy individuals were taken as controls. Plasma 25(OH)D, Fasting plasma glucose, post prandial glucose, lipid profile, A1C, and inflammatory markers (hsCRP) were measured. Anthropometric data were also obtained . Results: In our study out of 62 cases the mean age was 47.61±8.83 years and in 50 control the mean age was 47.54±9.49 years. The mean of plasma 25(OH)D was 18.90 ng/ml and percentages of vitamin-D deficiency and insufficiency were 64.51 % and 24.19 % respectively in metabolic syndrome patients group. The mean of plasma 25(OH)D was 23.91 ng/ml and percentages of vitamin D deficiency and insufficiency were 38% and 34% respectively in control group. Vitamin-D status was inversely associated with the serum TG, Waist Circumference, body mass index (BMI) ,elevated glucose levels ,hsCRP. And was positively correlated with HDL levels. Conclusion: Vitamin D levels were significantly decreased in metabolic syndrome patients as compared to control . Most metabolic syndrome components and glycemic profile were significantly correlated to serum 25(OH)D levels. The findings of this study revealed that vitamin D deficiency may have an important role in metabolic syndrome and its components.
Authors and Affiliations
Dr Ajeet Kumar Chaurasia
Keywords
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