Evaluation of Wound Healing Activity of Some Flavonoidal Drugs and Their Polyherbal Formulation on Wound Healing Models
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Tephrosia purpurea commonly known as Sarphank belongs to Fabaceae and its Aerial part used in the study. Asteracantha Longifolia which is commonly known as Kokilaksha, belongs to Acanthaceae Family and its Aerial part used. Trichopus zeylanicus commonly known as Arogyapacha belongs to Dioscoreaceae Family. Flavonoids are low molecular weight bioactive polyphenols which play a vital role in photosynthesising cells Flavonoids are secondary metabolites characterized by flavan nucleus and C6-C8-C6 carbon-skeletonAll These three plants Extract and their polyherbal formulation used for evaluation of wound healing activity by using Excision, Incision, Dead space and burn wound model. polyherbal formulation of all three selected plant material shows very strong wound healing potential as compare to Control and selected drug individually which was evidenced by Incresing wound contraction, Epithelization time, Increasing tensile strength and increasing wet, dry granuloam weight and hydroxiproline estimation in various wound models.
Authors and Affiliations
Gaurav Dubey, Anand Chaurasiya2, Ravindra Pal Singh3
Keywords
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