Exercise Capacity of Patients with Type 2 Diabetes: a Mini Review of Clinical Findings
Journal Title: Journal of Endocrinology and Diabetes - Year 2015, Vol 2, Issue 4
Abstract
In this mini review, we aimed to clarify the contributors to impaired cardiorespiratory fitness in patients with type 2 diabetes and to discuss how to improve cardiorespiratory fitness in this population. Patients with type 2 diabetes have low cardiorespiratory fitness even if the duration of their disease has been short and they have had no apparent diabetic complications or evident cardiovascular disease. Impaired cardiorespiratory fitness results in a sedentary lifestyle and an increased risk of cardiovascular and all-cause mortality. Conversely, physical inactivity exacerbates low cardiorespiratory fitness in this population. The pathognomonic factors in patients, such as impaired endothelial dysfunction and vascular conductance or mitochondrial dysfunction, contribute to reduced oxygen utilization in working muscles, which causes abnormal oxygen uptake kinetics during exercise. Clinically negligible diabetic cardiomyopathy, including left ventricular diastolic dysfunction and cardiac autonomic neuropathy, may also slow oxygen uptake kinetics and affect the cardiorespiratory fitness of a patient with diabetes. Although habitual exercise itself is the most efficient way to improve cardiorespiratory fitness, studies have suggested that patients with diabetes could benefit from thiazolidinedione to augment cardiorespiratory fitness.
Authors and Affiliations
Hisayo Yokoyama, Masanori Emoto
Keywords
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- EP ID EP333254
- DOI 10.15226/2374-6890/2/4/00129
- Views 134
- Downloads 0
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