Exocrine pancreas-brain axis – studies on pig models
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 5
Abstract
Biomedical research has proven that both diet and life style practices, including food compositiion, food quality, eating behavior, and physical activity profoundly affect the overall health status of the world’s population. New treatment approaches, including the use of functional food compounds can ameliorate the effects of the malnutrition which usually arises as a result of poor eating behaviours and poor food quality. Maldigestion, which is the main component of the malnutrition observed in modern society, is mainly a consequence of the lack of pancreatic enzymes. The absence or low level of pancreatic enzymes is commonly described as exocrine pancreas insufficiency (EPI). The EPI which occurs in newborns is an accepted physiologiocal state, while in the elderly it occurs as a result of age-related impairment of the exocrine pancreas. In both cases however, enzyme replacement therapy with pancreatic or pancreatic-like enzymes of microbial origin is applied to the patients. Pancreatic insufficiency (lack of active pancreatic enzymes in the gut) is often associated with marked neurological alterations related to cognitive function. However, studies dedicated to the investigation of brain function and morphology under conditions of malnutrition caused by EPI and the subsequent effects of dietary supplementation with pancreatic enzymes , are lacking – both in human and animal models.The main aim of the present review was to describe the effects of the presence of active pancreatic or pancreatic-like enzymes within the gut, on brain morphology and function in a pig model.
Authors and Affiliations
Kateryna Goncharova, Marek Pieszka, Rafal Filip, Stefan G. Pierzynowski
Keywords
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