Exploration of medication patterns and new formulas for patented Chinese herbal medicine compound therapy for colorectal cancer in the past 20 years
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 9
Abstract
Objective To analyze the medication usage and compatibility patterns of Chinese herbal medicine compound formulas in patents for intervening in colorectal cancer (CRC) over the past 20 years based on data mining, in order to provide a foundation for the development of new clinical medications. Methods Patented Chinese herbal medicine compound formulas for treating CRC were retrieved in the Wanfang database and China National Knowledge Infrastructure (CNKI) from their inception until January 17, 2024. Data analysis was performed using Excel 2019 software to assess drug frequency, properties, flavors, and meridian associations. SPSS Modeler 18.0 and SPSS Statistics 27 software suites were used for deriving drug association rules and performing cluster analysis. A complex network of core drug co-occurrences was constructed using Cytoscape 3.9.0 software to demonstrate associations of potential new formulations and new drugs. Results In total, 158 Chinese herbal medicine compound patents were included for CRC treatment, encompassing 448 Chinese herbal medicines. High-frequency medicines included Astragalus membranaceus (Huangqi), Hedyotis diffusa (Baihua Sheshecao), Poria cocos (Fuling), Atractylodes macrocephala (Baizhu), etc. The predominant type of medicine was deficiency-tonifying drugs, with the nature of the drugs being primarily cold and warm, and the flavors mostly bitter, sweet, and pungent. The meridians were chiefly associated with the liver, spleen, lung, and stomach. Herbs commonly used for pairs included Scutellariae barbatae Herba (Banzhilian), Astragalus membranaceus (Huangqi), Glycyrrhizae Radix et Rhizoma (Gancao), Atractylodes macrocephala (Baizhu), Poria cocos (Fuling), etc., while commonly used triangular medicines included Astragalus membranaceus (Huangqi) and Hedyotis diffusa (Baihua Sheshecao). There were four clusters of drugs, including Scutellaria barbata D. Don (Banzhilian)- Hedyotis diffusa (Baihua Sheshecao), and five groups of potential drugs, including “Phyllanthus emblica (Yuganzi)-Radix hedysari (Hongqi)-Semen punicae granati (Shiliuzi)-Zanthoxylum bungeanum (Chuanjiao)-Entada phaseoloides (Hetengzi)”. The core new formula for treating CRC was selected through topological attribute analysis. Conclusion Chinese herbal medicine patent formulas for treating CRC primarily use tonifying herbs, employing methods such as tonifying Qi and supporting the body, clearing heat and dampness, and resolving blood stasis and detoxification. The clustering of drugs focuses on Hedyotis diffusa (Baihua Sheshecao) and Scutellaria barbata D. Don (Banzhilian), which may offer new formulation ideas and provide reference for clinical treatment and new drug development for CRC.
Authors and Affiliations
ZHANG Zhaoyang , YANG Hao, WU Tengfei, ZHU Chongwei, TIAN Yun
Keywords
Related Articles
- EP ID EP745461
- DOI 10.13429/j.cnki.cjcr.2024.09.014
- Views 1
- Downloads 0
Reperfusion arrhythmias after percutaneous coronary intervention: a benign process? Or malignant injury?
Objective To study the clinical characteristics and risk factors of reperfusion arrhythmia (RA) after emergency interventional treatment in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods...
Evaluation of plasma atherogenic index on short-term prognosis of intravascular interventional therapy in patients with acute ischemic stroke
Objective To explore the role of plasma atherosclerotic index (AIP) in evaluating the short-term prognosis of endovascular intervention in acute ischemic stroke (AIS) patients of different age groups. Methods From Janu...
Visual analysis of domestic and international hotspots of nutritional research in children with tumors
<b>Objective</b> To analyze the literatures related to the nutrition of children with tumors at home and abroad, and sort out the current status, hotspots and frontiers of the research in this field, so as to provide a...
Research progress on denervation in cardiovascular diseases
Denervation is closely related to many cardiovascular diseases, such as myocardial infarction, myocardial ischemia-reperfusion injury, hypertension, arrhythmia, heart failure, atherosclerosis and ventricular remodeling....
Effect of resistance exercise on vasculardiastolic function and atherosclerosis in patients with hypertension
Objective To investigate the effect of resistance exercise on self-management ability, vascular diastolic function and atherosclerosis in patients with hypertension. Methods A total of 160 patients with hypertension trea...