Expression of VEGF in vitreous humor of patients with age-related macular degeneration and its relationship with inflammation
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 18, Issue 8
Abstract
AIM:To analyze the expression of vascular endothelial growth factor(VEGF)in vitreous humor of patients with age-related macular degeneration(ARMD)and its relationship with inflammation. <p>METHODS:Clinical data of 61 patients with ARMD(61 eyes)received treatment at our hospital from September 2016 to September 2017 were analyzed as Group A. And 25 idiopathic macular hole(IMH)patients(25 eyes)were enrolled as Group B. VEGF, IL-6 and IL-10 levels in vitreous humor were tested and compared between the two group. <p>RESULTS: Group A patients had higher levels of VEGF and IL-6 in vitreous humor than these of Group B patients, the difference were statistically significant(<i>t</i>=32.530, 8.443; <i>P</i><0.01). The level of IL-10 between the two groups was not significantly different(<i>P</i>>0.05). ROC analysis showed that the VEGF cut-off point value of 460.6pg/mL, as used for the differential diagnosis between ARMD and IMH, provided a sensitivity of 84.00%, a specificity of 93.44%, area under the curve(AUC)was 0.879, better than these of IL-6. Correlation analysis showed that, for Group A patients, the levels of VEGF had significant positive correlation with IL-6(<i>r</i>=0.787, <i>P</i><0.01). <p>CONCLUSION: The level of VEGF increased significantly in patients with ARMD and had positive correlation with inflammation, which can be used as an auxiliary diagnosis marker for ARMD from IMH.
Authors and Affiliations
Bing Wang
Keywords
Related Articles
- EP ID EP549315
- DOI 10.3980/j.issn.1672-5123.2018.8.43
- Views 113
- Downloads 0
Observation of β-amyloid plaques in retinas from live Alzheimer's model mice in different months
AIM: To study the correlation of β-amyloid(Aβ)plaques in retinas from Alzheimer's model mice in different months and progression of disease. <p>METHODS: Six-month(<i>n</i>=6)and twelve-month(<i>n</i>=6)old Alzheimer's mo...
EDI-OCT detecting retinal and choroidal thickness in patients with pregnancy induced hypertension
AIM: To observe and compare the changes of foveal retinal and choroidal thickness in patients with pregnancy-induced hypertension(PIH)by enhanced depth imaging optical coherence tomography(EDI-OCT). <p>METHODS: Totally 1...
Evaluation of clinical effectiveness of intrastromal corneal ring segments among keratoconus patients
AIM: To evaluate the clinical effectiveness of intrastromal corneal ring segments among the patients suffering from keratoconus. <p>METHODS: A retrospective and comparative interventional design had been utilized on the...
Efficacy of fenofibrate combined with 23G minimally invasive vitrectomy for diabetic retinopathy
AIM: To explore the application effect of fenofibrate combined with 23G minimally invasive vitrectomy in patients with diabetic retinopathy(DR). <p>METHODS: Totally 102 DR patients(102 patients)treated in our hospital fr...
Effects of amniotic membrane transplantation combined with limbal stem cell autograft transplantation on ocular burns
AIM: To investigate the effects of amniotic membrane transplantation combined with limbal stem cell autograft transplantation on ocular surface repair time, repair rate and complications in patients with ocular burns. <p...