Fabrication and Characterization of Cefixime Containing Micro Emulsion for Parenteral Drug Delivery System
Journal Title: Der Pharma Chemica - Year 2024, Vol 16, Issue 2
Abstract
The development of an injectable or parenteral micro emulsion formulation of the antibiotic cefixime was the aim of this investigation. We identified cefixime, which is easily soluble in methanol and propylene glycol and just slightly soluble in ethanol and acetone. Cefixime is directly dissolved in the aqueous buffer to create organic solvent-free aqueous solutions for use in biological experiments. To define the limits of a micro emulsion’s existence, pseudo ternary phase diagrams of oil, surfactant, cosurfactant (butanol/isopropyl alcohol mixture) and water were created. Cefixime was added to the ideal micro emulsion composition at 3, 6 and 9% w/w. We assessed the conductivity, solution viscosity and particle size of the cefixime micro emulsion. After being diluted in 5% dextrose for injection with 1 mg/ml cefixime, the micro emulsion’s stability and hemolytic activity were tested. The stability of the micro emulsion was evaluated after three months of storage at 4 and 25°C. Based on solubility data, sesameoil/soybean oil/olive oil was chosen as the oil phase for the cefixime micro emulsion. Based on weight percent, the ideal cefixime micro emulsion formulation was 2.0 % cefixime, 9% oil (Soybean oil/sesame oil), 24% Tween 40, 8% butanol, 4% isopropyl alcohol and 52.5% water. The optimized blank and drug-loaded micro emulsions had average particle sizes of 68.7 nm and 71.6 nm, respectively and these values remained constant after being diluted with dextrose 25 times. A three-month stability investigation at 4 and 25°C verified the findings of the cefixime chemical and micro emulsion physical tests. Erythrocytes appeared to tolerate cefixime micro emulsions well according to in vitro hemolysis experiments. Cefixime's unique micro emulsion formulation, which is appropriate for parenteral administration, was created. In comparison to the existing marketable formulation of cefixime based on voxpime® and isopropyl alcohol solution, this novel formulation may have fewer side effects related to vehicles.
Authors and Affiliations
Ashish Jain, Bhushan Hatwar and Akhlesh Kumar Singhai
Keywords
Related Articles
- EP ID EP742507
- DOI 10.4172/0975-413X.16.2.293-300
- Views 27
- Downloads 0
In-Situ Gel Systems for Ocular Therapeutics: Unveiling the Impact of Polymer Selection
A major problem in ocular therapeutics is the attainment of optimal drug concentration at the site of action, which is mainly due to precorneal loss resulting in only a small fraction of the drug being ocularly absorbed....
Current Trends for Regulatory Requirements of Elemental Impurity in Drug Substance for Regulatory Market
The presence of elemental impurities in drug substances has gained increasing attention in the pharmaceutical industry due to their potential impact on product safety and efficacy. Regulatory agencies worldwide have esta...
Green Synthesis and Evaluation of Pharmaceutical Properties of Euphorbia umbellata (Pax) Bruyns Latex
Present work explores the synthesis and application of Silver Nanoparticles (AgNPs) using latex from Euphorbia umbellata. The study characterizes the synthesized AgNPs and evaluates their antibacterial, antifungal and la...
Exploring the Potential Flavonoids as an Anti-Rheumatoid Arthritis Agent: An In silico Studies
Rheumatoid arthritis is an autoimmune disease which causes systemic complications, disability and even death. Its pathophysiology involves chronic inflammation of synovial membrane. New molecules in the biologic pathway...
Analytical Method Development for Dorzolamide Using UV Spectroscopy
The development and evaluation of an analytical technique for the UV spectroscopy based determination of Dorzolamide is the main focus of this study. Dorzolamide, a carbonic anhydrase inhibitor, is utilized to reduce int...