Fabrication and Characterization of Cefixime Containing Micro Emulsion for Parenteral Drug Delivery System
Journal Title: Der Pharma Chemica - Year 2024, Vol 16, Issue 2
Abstract
The development of an injectable or parenteral micro emulsion formulation of the antibiotic cefixime was the aim of this investigation. We identified cefixime, which is easily soluble in methanol and propylene glycol and just slightly soluble in ethanol and acetone. Cefixime is directly dissolved in the aqueous buffer to create organic solvent-free aqueous solutions for use in biological experiments. To define the limits of a micro emulsion’s existence, pseudo ternary phase diagrams of oil, surfactant, cosurfactant (butanol/isopropyl alcohol mixture) and water were created. Cefixime was added to the ideal micro emulsion composition at 3, 6 and 9% w/w. We assessed the conductivity, solution viscosity and particle size of the cefixime micro emulsion. After being diluted in 5% dextrose for injection with 1 mg/ml cefixime, the micro emulsion’s stability and hemolytic activity were tested. The stability of the micro emulsion was evaluated after three months of storage at 4 and 25°C. Based on solubility data, sesameoil/soybean oil/olive oil was chosen as the oil phase for the cefixime micro emulsion. Based on weight percent, the ideal cefixime micro emulsion formulation was 2.0 % cefixime, 9% oil (Soybean oil/sesame oil), 24% Tween 40, 8% butanol, 4% isopropyl alcohol and 52.5% water. The optimized blank and drug-loaded micro emulsions had average particle sizes of 68.7 nm and 71.6 nm, respectively and these values remained constant after being diluted with dextrose 25 times. A three-month stability investigation at 4 and 25°C verified the findings of the cefixime chemical and micro emulsion physical tests. Erythrocytes appeared to tolerate cefixime micro emulsions well according to in vitro hemolysis experiments. Cefixime's unique micro emulsion formulation, which is appropriate for parenteral administration, was created. In comparison to the existing marketable formulation of cefixime based on voxpime® and isopropyl alcohol solution, this novel formulation may have fewer side effects related to vehicles.
Authors and Affiliations
Ashish Jain, Bhushan Hatwar and Akhlesh Kumar Singhai
Keywords
Related Articles
- EP ID EP742507
- DOI 10.4172/0975-413X.16.2.293-300
- Views 18
- Downloads 0
Development and Validation of Simplified RP-HPLC Method for Quantification of Candesartan Cilexetil in Commercial Formulations
In order to produce antihypertensive effects, Candesartan Cilexetil (CC), a candesartan inactive prodrug, was quickly converted into active candesartan after absorption in the Gastrointestinal (GI) tract. This research s...
Protein Assembly: An Understanding and Clarification
Alzheimer's disease is characterized by the accumulation of mis folded proteins that form fibrillary amyloid deposits in specific regions of the central nervous system. This leads to memory loss, changes in personality,...
Recent Advancement of Phyto-Formulation in the Treatment of Neurodegenerative Diseases
Pharmacological molecular pathways during an epileptic episode and dementia were examined in the current review, which offers a helpful therapeutic approach for the treatment of neurological illnesses. The current resear...
The Effects of Bioactive Components Derived from Fruit on Different Types of Cancer: Mechanistic Pathways and Settings Associated to Stress
Background: Cancer is the world's leading cause of death today. Cancer patients' outcomes have significantly improved as surgery, radiotherapy and pharmaceuticals have advanced. Main body: fortunately the basic mechanism...
Triazole Benzene Sulfonamides as Leads for Human Carbonic Anhydrase IX Inhibition: Updates on Research Progress
Introduction: Triazole moiety is considered as the most important heterocyclic therapeutic agent in medicinal chemistry. Identifying a lead compound or potential drug, with the requisite physical and biological character...