Factor VII-401 and -402 polymorphisms and acute myocardial infarction in southern Turkey population
Journal Title: The European Research Journal - Year 2019, Vol 5, Issue 5
Abstract
Objectives: Factor VII has a crucial role in the extrinsic coagulation pathway and initiates the thrombus formation. Some studies showed that high plasma factor VII level was related to increased acute myocardial infarction (AMI) risk. But, some studies were reported opposite findings. Some polymorphisms can change the factor VII level. There is limited information about factor VII polymorphisms in southern Turkey population. Our aim was to determine the frequencies of Factor VII-401 and -402 polymorphisms and their relation to AMI in southern Turkey area. Methods: We enrolled 83 patients with AMI and 71 healthy subjects. Routine laboratory tests and factor VII-401 and -402 polymorphisms were determined from blood samples. Factor VII -401 and -402 polymorphisms were analyzed by LightCycler device using Real-Time PCR technique. Results: Family history of coronary artery disease and smoking frequencies were higher in patients group (p < 0.001 and p = 0.013, respectively). Patients had higher LDL cholesterol (p = 0.011) level, and lower HDL cholesterol (p = 0.025) level compared to healthy subjects. Factor VII-401 and -402 polymorphism genotypes were not significantly different in both groups. Also allele frequencies were similar in both groups. Conclusion: Factor VII-401 and -402 polymorphisms do not seem to increase AMI risk in southern Turkey.
Authors and Affiliations
Yurdaer Dönmez, Hasan Koca, Yahya Kemal İçen, Mustafa Demirtaş
Keywords
Related Articles
- EP ID EP628114
- DOI 10.18621/eurj.421781
- Views 89
- Downloads 0
Efficacy of adjunctive treatment with trimetazidine for fragmented QRS among patients with ischemic heart failure: a propensity score match analysis
Objectives: Fragmented QRS (fQRS) is an indicator of nonhomogeneous ventricular activity caused by myocardial ischemia and fibrosis. The anti-ischemic agent trimetazidine (TMZ) added to pharmacological treatment appears...
Changes in cerebral blood flow in rheumatology patients treated with rituximab
Objective: We aimed to assess the effects of rituximab therapy on cerebral hemodynamics in rheumatic patients with transcranial Doppler (TCD) ultrasonography. Methods: The study included seven patients aged 20-65 year...
Investigation of the relationship between alexithymia and eating attitude, self-esteem and anger in women who applied to psychological counseling center
Objective: The main purpose of this study was to examine self-esteem, anger and eating attitude with alexithymia in people who consult to the psychological counseling center. The sample of the study consist of 100 women...
Ischemic stroke due to minor head trauma in a child: a case report
Head trauma usually causes hemorrhage, but in children ischemia of basal ganglia may develop. Traumatic stroke occasionally develops after dissection of brain vessels, leading to disseminated cerebral embolism. Stretchin...
Tingling in tongue due to alprazolam and paroxetine-induced hypergabaergic activity
Paroxetine is a commonly used serotonin-reuptake inhibitor for the treatment of various psychiatric disorders. Available literature is sparse with cases of paresthesia that occur during withdrawal of paroxetine, there ar...