Factors affecting the efficacy of treatment and recurrence in intravitreal ranibizumab applications in neovascular age-related macular degeneration
Journal Title: Dicle Tıp Dergisi - Year 2015, Vol 42, Issue 2
Abstract
Objective: To evaluate the efficacy of intravitreal ranibizumab treatment and factors affecting the treatment in neovascular type age-related macular degeneration Methods: Ranibizumab injected 60 eyes of 60 patients with the diagnosis of neovascular age-related macular degeneration in our clinic were analyzed retrospectively. After three consecutive 3-month follow-up dose injection, decision to perform re-injections was according to best corrected visual acuity, fundus fluorescein angiography and optical coherence tomography findings in consecutive month follow-up. Patients were evaluated in terms of number of ranibizumab injections, pre-treatment and follow-up best-corrected visual acuity, central macular thickness, factors affecting the treatment and recurrence. Results: 30 (50%) of patients were male and 30 (50%) were women with a mean age of 67 ± 9.14 (50-84). While pre-treatment visual acuity average of the cases was 1.12 ± 0.69 logMAR, at the end of 12th month was 0.92 ± 0.63 logMAR. While pre-treatment mean central macular thickness was 343.1 ± 97 µm, in the 12th month was 286 ± 75.5 µm. While the first 3 injections were enough in 20 (33.3%) eyes, but 40 (66.7%) eyes had to be re-injected. Average number of injections was 4.23 ± 1.21. While there was no significant correlation between recent functional and anatomical success with age, gender, type of lens and membrane type, more vision gain was obtained in patients with initial lower visual acuity. The age of patients, pre-treatment visual acuity, membrane type were found to have no significant effect on recurrence rate. Membranes with classic component required more injection than occult type. Conclusion: After intravitreal injection of ranibizumab which is safe and effective in neovascular type of age-related macular degeneration more vision gain was obtained in patients with initial lower visual acuity and presence of classic component initial higher visual acuity, lower age required more injection. Key words: Age-related macular degeneration, ranibizumab, vascular endothelial growth factor
Authors and Affiliations
Özlem Kuru, Burak Erden, Mustafa Elçioğlu
Keywords
Related Articles
- EP ID EP89608
- DOI 10.5798/diclemedj.0921.2015.02.0557
- Views 156
- Downloads 0
Smoking habits of factory workers and their thoughts about cessation of smoking
Objective: The aim of this study was to determine smoking habits, levels of nicotine dependence, thoughts about smoking and smoking cessation of workers. Methods: This descriptive and cross-sectional study was conducte...
Yoğun bakım ünitesinde HELLP Sendromu ve eklampsi hastalarına uygulanan plazmaferez tedavisinin etkinliği
Amaç: Çalışmamızda yoğun bakım ünitemizde HELLP Sendromu ve eklampsi tanılarıyla izlenen hastalara uygulanan plazmaferez tedavisinin etkinliği ortaya konulmuştur. Yöntemler: 2005-2010 yılları arasında yoğun bakım ünit...
Evaluation of nasal allergy with symptomatology and skin prick test in the children having chronic otitis media with effusion
Objective: In this study, the children, who has chronic otitis media with effusion were investigated according to symptomatology of allergic rhinitis and skin prick test and coexistence of allergic rhinitis. Material...
Blood Pressure Percentiles for School Children
Objective: The prevalence of hypertension in childhood and adolescence is gradually increasing. We aimed to investigate the blood pressure (BP) values of children aged 7-18 years. Methods: This study was conducted in...
Torakotomi sonrası analjezide, intravenöz tramadol ile hasta-kontrollü analjezi ve devamlı infüzyonun karşılaştırılması
Amaç: Çalışmamızda, torakotomi sonrası analjezide, intravenöz hasta kontrollü analjezi ve devamlı intravenöz infüzyonla uygulanan tramadolün analjezik etkinliği, tüketimi ve yan etkilerini karşılaştırmayı amaçladık. Ger...