FACTORS PREDICTIVE OF REMISSION IN STEROID SENSITIVE NEPHROTIC SYNDROME OF PAEDS -A Review
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 11
Abstract
Nephrotic syndrome (NS) is the commonest glomerular disorder in childhood. It is a chronic distressing disorder characterized by heavy proteinuria, hypoproteinaemia, edema and Hyperlipidemia. Nephrotic syndrome is a set of signs or symptoms that may point to kidney problems, a condition when large amounts of protein leak out into the urine. In children protein excretion of more than 40 mg/m2/hr. indicate presence of nephrotic syndrome. Edema is the predominant feature of nephrotic syndrome and initially develops around the eyes and legs. Despite the occurrence of relapses, steroid sensitive nephrotic syndrome (SSNS) has a good long term prognosis. As it often heralds a clinical relapse, significant proteinuria (+++ or more on albustix) for [greater than or equal to] 3 consecutive days (simplified as P3D in this letter) defines a relapse, resulting in steroid therapy before the onset of edema. The 1st line treatment given is steroid therapy in the pre-antibiotic era children with NS often died, usually from overwhelming infections arising as a result of the immunosuppression which is an inherent feature of the disease and, poor nutrition. The importance of the immune system in the pathogenesis of childhood NS was first suggested in 1974. However, even many decades before this, it was known that after an attack of measles, NS could enter long term remission. But Corticosteroids have reduced the mortality rate to around 3%. The review paper describes interesting findings which have been observed , recorded and reported on this subject.
Authors and Affiliations
Syeda Javaria Nadir , Nazish Saleem , Fatima Amin , Khawaja Tahir Mahmood
Keywords
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