Feasibility of Platelet Indices as Possible Biomarkers in Evaluation of Initial Vascular Risks in Non-Diabetic Subjects.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
A possible role of platelet indices in non-diabetic subjects was explored for its possible association with hematopoietic and renal biochemical indices. Hypothesis was that non-diabetic disease burden is closely associated with change in serum levels of lipoproteins, urea, uric acid, creatinine, microalbumin and hematological parameters as consequence of platelet dysfunction manifested as dyslipidemia, nephrosis and thrombosis. A total of 97 non-diabetic patients out of 225 were analyzed for correlation and contribution of serum sugar, lipoproteins, urea, uric acid, creatinine, microalbumin and hematological parameters with platelet dysfunction as ‘pleiotropic risk index’. Results showed that ‘pleiotropic risk index’ may reflect the initial trigger of dyslipidemia, followed by progressive renal complications with growing risk of thrombosis in non-diabetic subjects. Males in their fifties age were at high risk of pleiotropic effects. Change in serum levels of sugar, lipoproteins, urea, uric acid, creatinine and microalbumin contribute as pleiotropic factors with increased risks in the order of lipids < platelet indices < urea < creatinine < microalbumin < hematological parameters < uric acid. Deranged platelet indices were closely associated with initial vascular and renal complication in nondiabetic subjects. In conclusion, non-diabetic pleiotropic effects associated with platelet indices, biochemical and hematopoietic biomarkers served as better risk indicators of progressive vascular complications in nondiabetic patients having chronic kidney disease.
Authors and Affiliations
Rajiv Kumar Ranjan, Sabiha Ashraf, Sompal Singh, Harender Beer Singh, Madhur Kudesia, Rakesh Sharma
Keywords
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- EP ID EP431012
- DOI 10.9790/0853-1801034248.
- Views 36
- Downloads 0
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