Flurbiprofen: β-cyclodextrin formulations: an improved method for fast dissolving tablet
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 5
Abstract
The goal of the present investigation was to design and evaluated taste mask of fast dissolving tablet of Flurbiprofen, by addition of super-disintegrant method using various excipients ,Ac-di-sol, Avicel, Manitol and β-Cyclodextrin (β-CD).Flurbiprofen is an anti-inflammatory and analgesic drug used in the treatment of chronic rheumatoid diseases which is a painful condition and therefore requires drugs that has rapid onset of action The feasibility of formulating the β-cyclodextrin complexes of Flurbiprofen (1:3) into tablet dosage forms is evaluated. Solid inclusion complexes of Flurbiprofen prepared by kneading method were formulated into tablets by direct compression methods. All the tablets formulated employing β- cyclodextrin complexes of Flurbiprofen gave rapid and higher dissolution rates of when compared to that of Flurbiprofen plain tablets. The prepared formulations were evaluated for hardness, friability, and disintegration time, wetting time, drug content and in-vitro drug release studies. Fast dissolving tablet prepared by addition of super-disintegrant method with Ac-di sol (4-8%) showed 99.85% in 12 minute. On the various data obtained showed that the use of super-disintegrants to formulate fast dissolving tablets of Flurbiprofen was a good way to enhance bioavailability, dissolution rate and absorption rate of the drug.
Authors and Affiliations
Pravin Khirwadkar, Kamlesh Dashora
Keywords
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