Folate Up-to-date
Journal Title: Journal of Analytical Bio-Science - Year 2012, Vol 35, Issue 4
Abstract
Folate is one of essential vitamin, and vital to normal cell growth and DNA synthesis. Folate deficiencies lead to megaloblastic anemia and ultimately to severe neurological problems. Folate concentration can be different depending on methods used for assessments. Therefore, there are needs for international reference materials as well as universal cutoffs of the deficiencies so that population prevalences of the deficiency can be properly determined and compared. Recently, World Health Organization (WHO) International Standard (IS) 03/178 and Standard Reference Material (SRM) 1955 were launched as reference materials for serum folate. These materials were determined using isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS). As a consequence, the restandardized Access folate assay, with WHO IS 03/178, is upcoming. In addition, WHO Technical Consultation defined the cutoffs for folate deficiencies.
Authors and Affiliations
Kazuko Nishimura, Kazuo Mori
Keywords
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