FORMULATING TASTE-MASKED ORALLY DISINTEGRATING TABLETS OF A BITTER DRUG IBUPROFEN
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 11
Abstract
This study is aimed at formulating taste-masked orally disintegrating tablets of a bitter drug i.e., Ibuprofen. Taste masking was carried out by fluid bed coating of extruded and spheronized pellets comprising of Ibuprofen, microcrystalline cellulose and lactose. Two marketed taste-masking systems, namely Eudragit EPO and Opadry tm were evaluated. For the formulation of orally disintegrating tablets a range of excipients such as super disintegrants, diluents, sweeteners and flavours were evaluated and a prototype formulation was selected. This prototype formulation had Eudragit EPO coated taste masked pellets and selected excipients. Its disintegration time was found to be about 8 seconds. Tablets were evaluated for their taste, disintegration time, hardness, friability, water uptake and drug release profile. It was concluded from this study that water insoluble, water permeable polymer system like Eudragit EPO can effectively taste mask bitter drugs without unduly affecting their drug release profile. As per objective of the work, the formulation was found to have a disintegration time of less than 30 seconds (about 8 seconds), had good mouth feel and organoleptic properties. With Eudragit EPO the bitterness and burning sensation of drug was significantly masked at low coating levels (15 %) without affecting the Ibuprofen release.
Authors and Affiliations
Naresh Kothapally , Sandeep Devareddy
Keywords
Related Articles
- EP ID EP99100
- DOI 10.7897/2230-8407.041117
- Views 121
- Downloads 0
EVALUATION OF ANTI-OXIDANT, CYTO-TOXIC AND ANTI-MICROBIAL PROPERTIES OF DRYNARIA QUERCIFOLIA
Drynaria quercifolia is a plant having wide spread ethno pharmacological uses. The aim of this study was to evaluate the anti-oxidant, anti-microbial and cyto-toxic activities of the whole plant Drynaria quercifolia. The...
BIOCHEMICAL ANALYSIS OF CABBAGE (BRASSICA OLERACEA) AFTER INFECTION OF PEST
Plants of Brassicaceae family include worldwide commercially grown crops. Experiments on this crop were conducted during the year 2011 in Vidhania and Jaisinghpura of Jaipur district Rajasthan, India. The aim of this stu...
IN VIVO EVALUATION OF IMMUNOMODULATORY POTENTIAL OF FERULIC ACID
Immunology is a branch of biomedical science that involves all aspects of the immune system that recognize pathogens and initiate defense response that involve induction, expression, amplification or inhibition of phase...
DEVELOP A NEW RP-HPLC METHOD AND VALIDATION FOR QUANTITATIVE DRUG CONTENT DETERMINATION OF EZETIMIBE FROM MARKETED FORMULATED TABLETS
This study has done to develop a cheap, reliable and stable method for the drug content determination of Ezetimibe from its formulated tablets. A binary reversed–phase (C18-Column) high performance liquid chromatograph w...
EVALUATION OF ANTI-INFLAMMATORY EFFECT OF CALOTROPIS PROCERA PROCERA (AIT.) R.BR. ROOT EXTRACT AGAINST DIFFERENT MEDIATORS OF INFLAMMATION IN ALBINO RATS
Calotropis procera (Ait) R Br had been widely used for its reported biological activities in indigenous system of medicine. The present investigation was carried out to find the effect of methanolic extract of root of Ca...