FORMULATION AND CHARACTERIZATION OF MATRIX TABLETS USING MUCILAGE OF TINOSPORA CORDIFOLIA AS NATURAL BINDER
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 7
Abstract
Objective: The present research work was to formulate matrix tablets of diclofenac sodium using mucilage extracted from Tinospora cordifolia as a novel binding agent. Also, a comparative study on binding properties of mucilage and carbopol were performed.Methods: Fresh stems of Tinospora cordifolia were collected and mucilage was extracted out using standard method. The isolated mucilage was characterised for physicochemical parameters. Formulation of diclofenac sodium tablets (f1-f6) was done by dry granulation method using 2%, 4%, 6%, 8% and 10% concentration of mucilage of Tinospora cardifolia as natural binder. Carbopol 2% was used as synthetic matrix forming agent. Microcrystalline cellulose was used as diluents, magnesium stearate and talc as lubricant. The formulated tablets were evaluated for parameters such as tablet thickness, hardness, weight variation, disintegration time, percent friability and in vitro drug release characteristics. The drug release mechanism was determined by fitting the release data into different kinetics models.Results: The results revealed that all the pre and post compression parameters of the formulated tablets (f1-f6) were in compliance with pharmacopoeial limits. In vitro drug release studies showed that formulation f6 containing maximum concentration of mucilage release the drug in a most controlled and sustained manner with maximum drug release of 63.6% in 15 h in comparison with f1(2% carbopol) giving 80% release and was found to be stable for 3 mo as indicated by stability studies. The mechanism of drug releases from formulation f1-f6 was found to be polymer disentanglement and erosion. Preformulation studies using FTIR study reveals that there is no incompatibility between the pure drug and mucilage of tinospora cardifolia used.Conclusion: Based on the experimental findings it can be concluded that Tinospora cordifolia mucilage can be used as a release retardant agent in the formulation of sustained release dosage forms.
Authors and Affiliations
Reecha Madaan, Rajni Bala, Tejeswini Vasisht, Ritima Sharma, Shivali Garg
Keywords
Related Articles
- EP ID EP566212
- DOI 10.22159/ijpps.2018v10i7.25447
- Views 51
- Downloads 0
HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACT OF CAESALPENIA BONDUC AGAINST CCL4 INDUCED CHRONIC HEPATOTOXICITY
Objective: The leaves of Caesalpinia bonduc (CB) have been used against various disorders in folk medicine including the liver disorders. Earlier, we have shown the hepatoprotective effect of CB in acute hepatotoxicity m...
FORMULATION OF KETOCONAZOLE LOADED NANO DISPERSIVE GEL USING SWOLLEN MICELLES TECHNIQUE AND ITS IN VITRO CHARACTERIZATION
Objective: The objective of the present work was to formulate and characterize nano dispersive gel (NDG) for topical delivery of water-insoluble antifungal agent ketoconazole in order to enhance its solubility, penetrati...
FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE IBUPROFEN TABLETS WITH ACRYLIC POLYMERS (EUDRAGIT) AND HPMC
Objective: An attempt was made to develop sustained release matrix tablets of ibuprofen using HPMC (K4M, K15M & K100M) and eudragit (RS 100 & RL 100) as release retardant polymers.Methods: The ibuprofen matrix ta...
FRUIT PEEL EXTRACTS WITH POTENTIAL FOR DISSOLVING SIMULATED RENAL STONES IN IN VITRO CONDITIONS
Objective: To evaluate the antiurolithiatic activity of selected fruit peels on simulated renal stones in in vitro conditions.Methods: Simulated renal stones were prepared by homogenous precipitation method. The criterio...
A VALIDATED STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS DETERMINTION OF ATORVASTATIN CALCIUM AND EZETIMIBE HYDROCHLORIDE IN BULK AND TABLET DOSAGE FORM
Objective: To develop a simple, selective and precise stability indicating reverse-phase high performance liquid chromatography method for the simultaneous estimation of atorvastatin calcium and ezetimibe hydrochloride i...