Formulation and Evaluation of Aceclofenac Solid Dispersion for Improving the Solubility and Dissolution Rate
Journal Title: International Journal of Pharmaceutical Science Invention - Year 2017, Vol 6, Issue 10
Abstract
Aceclofenac is a novel non-steroidal anti-inflammatory drug (NSAID) having anti-inflammatory and analgesic properties. It is widely used in the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. For overcoming this problem, we have designed a research work to formulate solid dispersions (SDs) of Aceclofenac which was prepared using Kneading method with the carrier PEG, urea and guar gum to increase its aqueous solubility. Aceclofenac SDs were prepared in 1:1, 1:3 and 1:5 ratios of the drug to polymer. Physicochemical evaluation was performed such as p H study, dissolution study, solubility study. In-vitro release profiles of all formulations (F-1 to F-9) were comparatively evaluated and also studied against pure aceclofenac and visual inspection. The concentration of diffused drug was measured using UV-visible spectrophotometer at λmax= 276 nm. Among the carriers faster dissolution was exhibited by the formulations of SD containing urea than PEG and Guar gum. The experimental results show that the solid dispersion of Aceclofenac has improved dissolution rate and the formulated system shows good bioavailability in a short time. Highest solubility percentage (42.25%) was found for F-8; and F-7 showed highest dissolution rate in 60 minute (87.92%). The increase tendency of dissolution rate of the drug may be due to increase in wettability, hydrophilic nature of the carrier and due to reduction in drug crystallinity. However, further investigation is required to establish in-vivo and in-vitro correlation to confirm the accurate pattern of drug release from Aceclofenac SDs for potential therapeutic use.
Authors and Affiliations
Reeka Chowdhury, Rubaiya Anjum, Shafayet Ahmed Siddiqui, Md. Zahidur Rahman, Tusnova Sharmin, Md. Mamun Or Rashid
Keywords
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