FORMULATION AND EVALUATION OF CAPTOPRIL MICROENCAPSULES: A SUSTAINED RELEASE APPROACH
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The aim of the present study is to formulate and evaluate Captopril micro-encapsules. Microspheres and micropellets of captopril prepared with different polymers through the techniques of microencapsulation were found to have a good spherical shape, and were non-aggregated exhibiting good flow properties. In addition, all the formulations prepared, showed good drug incorporation efficiency and an extended release of the drug, thereby enhancing the duration of action. The different techniques used in the preparation such as, emulsion-phase separation, solvent-evaporation and ionotropic-gelation techniques were found to be simple and reproducible. All the polymers used viz., chitosan, ethyl cellulose, sodium alginate and Hydroxy propyl methyl cellulose (HPMC) were economic, easily available and biocompatible. The industrial applicability of the methods would be simple and rapid, provided the work being extended to in-vivo studies. It is obvious from the above work that, the study has engineered a drug delivery profile in which the drug release is controlled to a great extend and that the formulations in therapy can minimize untoward side effects, thus improving patient compliance.
Authors and Affiliations
Harish Gopinath, Koteswararao Pasupuleti, Debjit Bhowmik, Duraivel S
Keywords
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