FORMULATION AND EVALUATION OF CEFPODOXIME PROXETIL SUSTAINED RELEASE MATRIX TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
Formulation of Cefpodoxime proxetil extended release matrix tablets. The aim of the present study is to develop a pharmaceutically stable, once a day robust formulation which will have similar clinical efficacy as that of twice a day formulation of 200mg strength and can reduce dosage frequency. Cefpodoxime proxetil is used in the treatment of respiratory and urinary tract infections. In the present study, the polysaccharides guargum and xanthum gum were evaluated as carriers for colon targeting by formulating matrix tablets of cefpodoxime proxetil with different concentrations (5%,10%,20%,40%) of the above polysaccharides. Tablets were prepared by wet granulation method. Formulation containing 40% guargum is considered as optimized formulation as it releases less amount of drug in first 2 hours compared to other formulations. The optimized formulation was subjected to stability studies as per ICH guidelines at accelerated condition for 3 months and was found to be stable.
Authors and Affiliations
Divya Palparthi, K. Narendra Kumar Reddy
Keywords
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