Formulation and evaluation of gastro retentive nifedipine floating tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
The objective of present investigation is to develop and evaluate Gastro retentive floating tablets of Nifedipine to achieve controlled drug release with reduced frequency of drug administration, reduced side effects and patient compliance and to prolong the drug release in GIT and consequently into the plasma. Nifedipine is a calcium channel blocker of the dihydropyridine type, mainly used for the treatment of hypertension and angina pectoris. Nifedipine is a suitable candidate for Controlled Release administration due to its short elimination time 2-4 hrs. Controlled release matrix tablets of Nifedipine were prepared by using polymers like HPMCK100, Ethyl cellulose, Micro crystalline cellulose, PVP-K30, Guar gum, Xanthan gum and Magnesium stearate. Nifedipine controlled release matrix tablets were prepared by direct compression method. The powder blend was subjected for pre-compression parameters such as bulk density and tapped density, angle of repose, compressibility index and hausner’s ratio. The prepared tablets are evaluated to post-compression parameters such as hardness, friability, average weight, drug content, buoyancy studies, swelling index and in-vitro dissolution studies. Drug compatibility with excipients was checked by FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. The values of post-compression parameters evaluated were within acceptable limits. The dissolution profiles of all the formulations were evaluated. Amongst all the formulations, the release profile of formula F5 gave optimum results up to 10hrs. It was concluded that Nifedipine controlled release matrix tablets F5 is successful formulation and can be manufactured with reproducible characteristics from batch to batch. The optimized formulation (F5) was compared to the marketed product and hence found to be superior over the marketed product.
Authors and Affiliations
Shabana Parveen, Debjit Bhowmik, Praveen Khirwadkar, K. P. Sampath Kumar, Rajnish Kumar Singh
Keywords
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