Formulation and evaluation of gastro retentive nifedipine floating tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
The objective of present investigation is to develop and evaluate Gastro retentive floating tablets of Nifedipine to achieve controlled drug release with reduced frequency of drug administration, reduced side effects and patient compliance and to prolong the drug release in GIT and consequently into the plasma. Nifedipine is a calcium channel blocker of the dihydropyridine type, mainly used for the treatment of hypertension and angina pectoris. Nifedipine is a suitable candidate for Controlled Release administration due to its short elimination time 2-4 hrs. Controlled release matrix tablets of Nifedipine were prepared by using polymers like HPMCK100, Ethyl cellulose, Micro crystalline cellulose, PVP-K30, Guar gum, Xanthan gum and Magnesium stearate. Nifedipine controlled release matrix tablets were prepared by direct compression method. The powder blend was subjected for pre-compression parameters such as bulk density and tapped density, angle of repose, compressibility index and hausner’s ratio. The prepared tablets are evaluated to post-compression parameters such as hardness, friability, average weight, drug content, buoyancy studies, swelling index and in-vitro dissolution studies. Drug compatibility with excipients was checked by FTIR studies. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. The values of post-compression parameters evaluated were within acceptable limits. The dissolution profiles of all the formulations were evaluated. Amongst all the formulations, the release profile of formula F5 gave optimum results up to 10hrs. It was concluded that Nifedipine controlled release matrix tablets F5 is successful formulation and can be manufactured with reproducible characteristics from batch to batch. The optimized formulation (F5) was compared to the marketed product and hence found to be superior over the marketed product.
Authors and Affiliations
Shabana Parveen, Debjit Bhowmik, Praveen Khirwadkar, K. P. Sampath Kumar, Rajnish Kumar Singh
Keywords
Related Articles
- EP ID EP33279
- DOI -
- Views 278
- Downloads 0
Potential Impact of Nanomaterials in Information and Communication Technologies
Nanomaterials are throwing the doors open to a hyper-tech era in which electronics and information and communication technology (ICT) are going to become ubiquitous. Enormous progress has been made by making a transiti...
EVALUATION OF ANTI-DIARRHOEAL ACTIVITY OF ETHANOLIC LEAF EXTRACT OF SCOPARIA DULCIS LINN ON WISTER ALBINO RATS
The objective of the study was to find out the ethanolic extract of the leaves of Scoparia dulcis Linn for antidiarrhoeal effects on Wister albino rats. The extract was evaluated for castor oil- induced diarrhoea and i...
EFFECT OF HYDROTROPIC SOLUTE ON In-VitroCHARECTERIZATION OF VALSARTAN FAST DISINTEGRATING TABLETS
Valsartan is an angiotensin receptor antagonist, commonly called as “angiotensin receptor blocker", or angiotensin receptor blocker. Solubility is an important physicochemical factor affecting absorption of drug and it...
DEVELOPMENT AND VALIDATION OF PEMETREXED BY RP-HPLC METHOD IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORMS
A simple rapid, accurate, precise and reproducible validated reverse phase HPLC method was developed for the determination ofCeftazidimepentahydrate and Tazobactam sodium in bulk and pharmaceutical dosage forms. The qu...
Evaluation of nephroprotective activity ethanolic extract of stem bark extract of Tephrosia purpurea
Objective: To evaluate the nephroprotective activity of Ethanolic extract of Tephrosia purpurea (T.purpurea) (Fabaceae) in Gentamycin and Cisplatin-induced acute renal failure in rats. Materials and Methods: Tephrosia...