Formulation and Evaluation of Colon Targeted Oral Drug Delivery System for Meloxicam
Journal Title: Scholars Academic Journal of Pharmacy - Year 2015, Vol 4, Issue 1
Abstract
In the present research work sustained release matrix formulation of Meloxicam targeted to colon by using various polymers developed. Meloxicam is a selective cyclooxygenase-2 inhibitor with pH-dependent solubility. To achieve pH-independent drug release of meloxicam, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F3 formulation was found to be optimized as it was retarded the drug release up to 12 hours and showed maximum of 98.69% drug release. It followed zero order kinetics mechanism. Keywords: Colon targeted drug delivery system, Meloxicam, in vitro dissolution, release kinetics
Authors and Affiliations
Venkateswara Reddy, Muneer Syed, D. Srinivasa Rao
Keywords
Related Articles
- EP ID EP376874
- DOI -
- Views 128
- Downloads 0
Association between time and mortality of patients admitted from Emergency Department to Intensive Care Unit
Increasing patient population and refunds for hospital based health services lead over admissions to hospitals and emergency departments (ED). Increased patient ED admissions thus increased time-spend in ED and over-crow...
Evaluation of the Anticonvulsant Effect of the Methanol Extract of Evolvulus alsinoides in Mice
The purpose of this research work is to study the anticonvulsant activity of Evolvulus aisinoides Linn (convolvulacea) used in traditional medicine for the treatment of neurodegenerative diseases, amnesia, mental illness...
Activity of anti-cancer protein kinase inhibitors against growth of different stages of Leishmania spp.
Current situation of Leishmaniasis calls for search of more effective drug. Multiplication of Leishmania resembles the development of mammalian tumor cells and both are regulated by the same mechanisms and having similar...
In-Vitro Antioxidant Potential of Delonix regia Leaves
Antioxidants are an inhibitor of the process of oxidation, even at relatively small concentration and thus have diverse physiological role in the body. The present study was carried out to identify the phytochemicals and...
Validated UV Spectrophotometric Methods for the Estimation of Aceclofenac in Bulk and Pharmaceutical Formulation
Aceclofenac, 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl]oxyacetic acidis a non-steroidal anti-inflammatory drug (NSAID) used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankyl...