FORMULATION AND EVALUATION OF DEXLANSOPRAZOLE DELAYED RELEASE CAPSULES
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The present research work is formulation and evaluation of dexlansoprazole delayed release capsules. Dexlansoprazole is proton pump inhibitor (PPI) used in treatment of gastro esophageal reflux disease (G.E.R.D), Erosive esophagitis (E.E) and acid – related factors. In this research work various polymers like HPMC P55 S, Eudragit L 100 were used as enteric coating polymers were prepared in a fluidized bed coater (FBC). The pre-formulation studies such as solubility and compatability studies were carried out. In the formulation study of dexlansoprazole different formulation (F1 - F10) have been formulated and evaluated for acid resisitance, dissolution profile and release kinetics. The drug percentage release is more when compared with the marketed product. Stability study was done at various storage conditions and months for description, assay, water content, related substances. Mainly research work is to develop a pharmaceutically equivalent low cost quality improved and stable formulation and evaluation of dexlansoprazole delayed release capsules comparable to innovator product.
Authors and Affiliations
Peer Basha Syed, Chakravarthi V,Venkateswarlu B,Koteswararao P, Farooq Ahmed
Keywords
Related Articles
- EP ID EP33018
- DOI -
- Views 442
- Downloads 0
Micropropagation of an important medicinal plant Catharanthus roseus by using coconut water instead of synthetic plant growth regulators
The present in vitro study was conducted for micropropagation of Catharanthus roseus by using coconut water. The coconut water was used in five different concentrations i.e T1 (3 %), T2 (6 %), T3 (9%), T4 (12 %) and T5...
A REVIEW ON MEDICINAL PLANTS HAVING ANTIOXIDANT POTENTIAL
Natural compounds from plants and other life forms (bacteria, fungi, marine organisms) represent a major source of molecules with medicinal properties. Among them, antioxidant substances are of particular interest. The...
CONTROVERSIAL ROLE OF ANTIPSYCHOTICS IN THE TREATMENT OF ALZHEIMER’S DISEASE
Antipsychotics are the commonly prescribed drugs in the treatment of Alzheimer’s disease, which is the most common form of dementia. Atypical antipsychotics are an effective short-term (6-12 weeks) treatment in relievi...
Evaluation of in-vitro anthelminthic activity of leaf and bark aqueous extracts of Santalum album linn
Santalum album Linn is the most significant genus in the family Santalaceae, which is commonly known as Sri gandham in India. This study evaluates anthelmintic activity of Aqueous leaf and bark extracts of Santalum alb...
Formulation and Evaluation of Irbesartan Microspheres
In the present work, microspheres of Irbesartan using sodium alginate as a retarding polymer were formulated to deliver Irbesartan via oral route. The results of this investigation indicate that solvent evaporation met...