Formulation and Evaluation of Irbesartan Microspheres
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2018, Vol 6, Issue 1
Abstract
In the present work, microspheres of Irbesartan using sodium alginate as a retarding polymer were formulated to deliver Irbesartan via oral route. The results of this investigation indicate that solvent evaporation method can be successfully employed to fabricate Irbesartan microspheres. The technique provides characteristic advantages over conventional microsphere method, which involves an “all-aqueous” system avoids residual solvents in microspheres. Other methods utilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, and toxicity and difficult to remove traces of organic solvents completely. FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymer used. Micromeritic studies revealed that the mean particle size of prepared microspheres was within the size range and are suitable for microspheres for oral administration. Increase in the polymer concentration leads to increase in percentage yield, swelling property and in-vitro drug release studies. The in–vitro drug release study demonstrated that microspheres of Irbesartan using sodium alginate as a retarding polymer. The in-vitro drug release increased with increase in the polymer concentration. Analysis of drug release mechanism showed that the drug release from the formulations followed Non-Fickian diffusion and the best fit model was found to be Korsmeyer peppas. Based on the results of evaluation tests formulation coded F4 was concluded as best formulation.
Authors and Affiliations
Swathi Bonagiri, G. Pavan Kumar, M. Ramanujan , V. Jaya Sai Teja Sree, V. Mounika, T. Satyanarayana
Keywords
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