Evaluation of in-vitro anthelminthic activity of leaf and bark aqueous extracts of Santalum album linn
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 4
Abstract
Santalum album Linn is the most significant genus in the family Santalaceae, which is commonly known as Sri gandham in India. This study evaluates anthelmintic activity of Aqueous leaf and bark extracts of Santalum album Linn on Indian adult earthworms, Pheretima posthuma (annelid). Leaves and barks were extracted by using soxhlet apparatus. Photochemical screening of crude extracts showed the presence of Alkaloids, Glycosides, Carbohydrates, Flavonoids, Phenols and Tannins. Various concentrations (25, 50 & 100mg/ml) of crude extracts were tested on anthelminthic activity when involved the determination of the time of paralysis and time of death of worms. The activity was compared with standard Albendazole. The aqueous extract shows significant activity when compared to the standard Albendazole. The paralysis and death time is 64, 60, 55 and 78, 75, 70 minutes respectively at concentrations 25, 50 and 100mg/ml for the bark extract and 80, 74, 69 and 85, 82, 75 minutes respectively at concentrations 20, 50 and 100mg/ml for the leaf extract. Whereas these are 46, 40, 34 min and 62, 58, 50 minutes for Albendazole. In order to confirm the studies in-vivo studies have to be conducted.
Authors and Affiliations
N. Bhasker Babu, Cheekati vineetha, K. Bhavani, K. K. V. Sai Prasanna, K. Surya Kiran, P. Pushpa durga, T. Satya narayana
Keywords
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