Formulation and Evaluation of Ezetimibe Liquisolid Tablets: An Approach to Enhance the Dissolution Rate
Journal Title: Journal of Pharmaceutical Research International - Year 2015, Vol 7, Issue 6
Abstract
Background and the Purpose of the Study: Liquisolid compacts’ using poorly water soluble drugs is considering as one of the novel pharmaceutical formulation technologies to improve the dissolution rate. This study was intended to improve the dissolution rate of ezetimibe by preparing liquisolid tablets. Methods: In the preparation of liquisolid tablets, the following materials are used as carrier powder; polyethylene glycol (PEG) 400, tween 80 and propylene glycol as solvent, Avicel PH102 or starch or HPMC or PEG 4000 or PEG 6000 and Aerosil 200 are used as coating material. The interaction between drug and excipients was examined by differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). In vitro drug release studies of liquisolid and conventional tablets (control) were conducted and compared the both to study the improvement in dissolution rate. Then the best formulation was subjected to stability studies. Results and Discussion: The results of DSC and FTIR studies revealed that there are no possible drug-excipient interactions. The percentage drug release of ezetimibe at 10 min (Q10) and dissolution efficiency were increased from 23.86±1.08% and 11.61 for conventional tablet to 92.57±1.12% and 60.30 for the liquisolid formulation. From the stability studies, the similarity factor was found as above 50 that revealed the stability of the formulation. Conclusion: In conclusion, the liquisolid technique was believed as a capable approach to enhance the ezetimibe dissolution rate.
Authors and Affiliations
Sateesh Kumar Vemula, Saritha Aila, Vijaya Kumar Bontha
Keywords
Related Articles
- EP ID EP344708
- DOI 10.9734/BJPR/2015/19125
- Views 82
- Downloads 0
Synthesis of Silver Nanoparticles and Incorporation with Certain Antibiotic Using Gamma Irradiation
Aims: The study was explaining that silver nanoparticles (AgNPs) were synthesized biologically by Bacillus megaterium culture supernatant (as reducing and stabilizing agents) by the optimization of medium components for...
Cosmeceutical Benefit of Abelmoschus esculentus L. Seed Extract
Background: Abelmoschus esculentus L. or okra is a vegetable of Malvaceae family. Aim: Okra seeds were dried at 60°C, ground, and extracted by using absolute ethanol. The acquired extract was investigated for chemical c...
Comparative Study of Antioxidant and Anticancer Activity of Thuja orientalis Growing in Egypt and Saudi Arabia
Cancer is a life threatening diseases, caused by many factors including the oxidative stress. Some medicinal plants are rich with volatile oil represent an important source of antioxidant and anticancer drugs. This stu...
In vitro Antisalmonellal and Antioxidant Properties of Mangifera indica L. Stem Bark Crude Extracts and Fractions
Aims: Typhoid fever is still a major public health problem in developing countries, where it remains endemic. In view of searching for new antityphoid substances, the antisalmonellal and antioxidant properties of extract...
In silico Study of Transmural Dispersion of Repolarization in Non-failing Human Ventricular Myocytes: Contribution to Cardiac Safety Pharmacology
Aims: To investigate the putative usefulness of the in silico determination of transmural dispersion of repolarization (TDR) for early cardiac safety pharmacology. Study Design: Computational simulations. Place and Durat...