FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILMS OF FLUVASTATIN SODIUM BY USING TASTE MASKING TECHNIQUES
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 3
Abstract
Fluvastatin sodium, a HMG-COA reductase inhibitor has shorter half life (1.2). It undergoes extensive first pass metabolism, frequent dosing is required in case of conventional dosage form. It is an bitter drug so an attempt was made to mask the taste by using three masking techniques. The present investigation indicates the possibility of developing Fluvastatin sodium loaded fast dissolving oral films to enhance the oral bioavailability by avoiding first pass metabolism to provide a rapid onset of action. Solvent casting method was used to formulate the fast dissolving oral film. Different formulation F1–F6 was prepared by using Artificial Sweetening Agents and Flavors (Sucrose, Saccharin); by using Viscosity Modification Method (CMC, Sucrose, Saccharin); by using β-cyclodextrin complexed drug Freeze Drying Method (Cyclodextrin, Sucrose, Saccharin). All the formulation were subjected to evaluation by various parameter like visual inspection, weight variation, folding endurance, film thickness, disintegration time, drug content, in vitro drug release, taste masking evaluation. Result obtained indicates all formulation F1-F6 were thin, smooth, flexible and uniform in drug content, weight and thickness as observed with low S.D. values. F6 be the best formulation from drug content, % release, taste masking effect and all other parameters. % release for F6 was found to be 99.6% within 150 sec (2.5 min) which falls within the limit as per pharmacopoeia (5-20 min) for oral dissolving films. Hence indicates quick onset of action within seconds as the oro mucosal absorption of the drug occurs directly from the site of administration to systemic circulation avoiding first pass metabolism to produce the desired action i.e offered significant results in terms of improving taste and bioavailability.
Authors and Affiliations
Mandeep Kaur| Chandigarh College of pharmacy, Landran, Mohali, Panjab., Indu Bala| Chandigarh College of pharmacy, Landran, Mohali, Panjab., Anjoo Kamboj*| Chandigarh College of pharmacy, Landran, Mohali, Panjab., Upendra K Jain| Chandigarh College of pharmacy, Landran, Mohali, Panjab.
Keywords
Related Articles
- EP ID EP3733
- DOI -
- Views 420
- Downloads 18
EVALUATION OF VARIOUS SCREENING TESTS FOR DETECTION OF URINARY TRACT INFECTIONS
Background: Conventional urine cultures cannot be used routinely on large scale or when there is urgency in diagnosing urinary tract infections (UTI) or where the facilities are not available. In these instances screeni...
Immunoprecipitation of 11 ZN fingers Domains, CTCF and BORIS to Multifunctional Y-box DNA/RNA-binding factor, YB-1 in Glioma-RGBM
CCCTC binding factor (CTCF) is a unique highly conserved and ubiquitously expressed 11 zinc finger (ZF) transcriptional factor with multiple target site. It is able to bind to various target sequences to perform differen...
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS OF INDOMETHACIN IN RABBIT BLOOD PLASMA BY RP-HPLC TECHNIQUE
The objective of the present work involved the development of simple, rapid, sensitive and cost effective RP-HPLC method for the estimation and quantification of indomethacin in rabbit plasma to evaluate their linearity...
EVALUATION OF RAPID UREASE TEST IN DIAGNOSIS OF Helicobacter pylori AMONG GASTRODUDENITIS AND PEPTIC ULCER Patients IN COMPARISON WITH PCR IN KHARTOUM STATE
Background: Recently Helicobacter pylori (H. pylori) has been involved in many serious diseases such as peptic ulcer and ended with gastric cancer, which can be prevented using specific diagnostic test and treatment. O...
ANTIINFLAMMATORY AND ANTINOCICEPTIVE ACTIVITY OF MORINGA OLEIFERA
The Moringa plant, found in tropical and subtropical countries, provides a rich and rare combination of zeatin, quercetin, kaempferom and many other phytochemicals. It is very important for its medicinal value. Various...