Formulation and Evaluation of Floating Tablets of Atazanavir:
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 6
Abstract
The main aim of this research work on hydro-dynamical drug systems is to develop the Atazanavir controlled release tablets using floating technique to estimate the gastric retention time and the release kinetics with sustain release tablets and furthermore to keep up constant therapeutic effect of the drug for more than 12 hrs. The weight of atazanavir was settled as 400 mg and the aggregate weight of the tablet was considered as 600 mg. The polymers xanthan gum, karaya gum, guar gum, and carbopol were of 15, 30, 45 and 60 mg. From the dissolution studies conducted it was evident that the formulation (F14) showed better and desired drug release pattern i.e., 98.54 % in 12 hours. The drug followed zero order release kinetics with super case II mechanism.
Authors and Affiliations
Sahitya Lakshmi. K1, Shireesh Kiran. R, Vishnu. P .
Keywords
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