FORMULATION AND EVALUATION OF HPMC MICROSPHERES OF OXAPROZIN FOR SUSTAINED RELEASE
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2012, Vol 2, Issue 4
Abstract
Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilatation, and subsequent heat dissipation. The main objective of this research work was to prepare HPMC microspheres loaded with Oxaprozin and invitro drug release study. In the present study, emulsification-heat stabilizing method is used for preparing microspheres. The polymer (HPMC) and drug (Oxaprozin) was dissolved in deionsed water. Surfactant was added to this solution and stirred it for 30 min. The oil and 1% span-80 (as emulsifier) were mixed together and allowed to stir for 20 min at 800-1000 rpm. The aqueous phase was added to oil phase to form primary emulsion. This emulsion were added to preheated sunflower oil and stirred for 3 hrs at 1000-1200 rpm. Microspheres were filtered and dried in dessicator over night. Microspheres were spherical shape and smooth surface. Infra-red spectra showed identical peaks of drug and polymer drug entrapment efficiency was 69% determined by UV-Spectrophotometer at 267nm. In-vitro drug release studies were preformed using shaking flask method. The formulation ZM1 Showed 87.5% drug was released in 10 hrs. It is concluded that HPMC microspheres of Oxaprozin can be prepared by emulsification heat stabilizing method and in-vitro release data is satisfactory.
Authors and Affiliations
Ganesh kumar Gudas, Raghavendar Reddy Karedla, Annadi Chiranjeevi, T. Kashinath
Keywords
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