FORMULATION AND EVALUATION OF IRBESARTAN IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACE inhibitor is used in treatment of hypertension. Irbesartan tablet have been prepared by wet granulation method. Effect of various fillers and disintegrants were also explored. Microcrystalline cellulose, colloidal silicone dioxide, croscarmellose sodium were used in wet granulation. In order to obtain acceptable product several trials were conducted. Various pharmacopoeia evaluations of the formulations were conducted including weight variation, hardness, disintegration time, friability and in-vitro dissolution. Final selection of formulation was done based on pharmaceutical equivalence of development formulation to that of marketed one.
Authors and Affiliations
Deepak Galge , Rahul Raut , Senthil Adimoolam , Uday Masurkar , Vantoor Narayanaswamy
Keywords
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