FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM AND HYDROCHLORTHIAZIDE CONVENTIONAL RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 6
Abstract
The losartan potassium and hydrochlorthiazide tablets are prepared by using low substituted HPC as disintegrant. The addition of diuretics to angiotensin II receptor blockers will potentiate the action of angiotensin receptor blockers. The tablets are formulated using wet granulation technology using purified water as granulating agent. The tablets are evaluated for their weight, thickness, hardness, friability, disintegration and dissolution. A total of seven batches are punched and the first six are rejected as they do not complied with the specifications and the seventh batch is complied with all the specifications. The disintegrant used in the innovator product is croscarmellose and the disintegrant in the present study is low substituted hydroxy propyl cellulose. The dissolution profile of the optimised batch is compared with the innovator and the percentage drug release of the innovator product is 97% but it is increased to 99% as the disintegrant is changed.
Authors and Affiliations
Sandeep Devareddy , D. Krishnarajan , R. Manivannan , N. Senthilkumar
Keywords
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