Formulation and evaluation of losartan potassium ethosomal gel
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 2
Abstract
Clinically liposomal systems were found to be effective, at forming drug reservoir in the upper layers of the skin for local skin therapy. Recently, it was found that Ethosomal carriers were phospholipid vesicular systems having relatively high concentrations of alcohol, enhances dermal and transdermal delivery of both lipophilic as well as hydrophilic molecules. In the present work Ethosomal gels loaded with Losartan Potassium were designed to improve the patient compliance by reducing the frequency of dosing and the adverse drug reactions of Losartan Potassium. A novel vesicular carrier i.e. Ethosomes containing Losartan Potassium using different concentrations of ethanol and Soy lecithin by cold method, caused its size reduction by sonication. Potassium is a potent anti-hypertensive drug (Angiotensin II (AT1) receptor blocker) and a hydrophilic agent has limited transdermal permeation. In the cold method; lecithin was used as the vesicle forming agent and Poly glycol, Ethanol were used as skin permeation enhancers. The size of the ethosomes was optimized by varying the concentration of lecithin and ethanol. The prepared ethosomes were evaluated for compatibility with the excipients, vesicular size, shape, entrapment efficiency, stability, skin irritation; wash ability, optimum pH, drug content, uniformity and in-vitro drug permeation. Microscopic examinations suggested that ethosomes are soft, malleable and spherical vesicles with a smooth surface. Among the formulations, the EF4 containing 3% lecithin and 30% ethanol emerged to be the overall best formulation based on the in-vitro drug release. Skin irritation study revealed that the system is free of irritation.
Authors and Affiliations
L. Mohan Krishna, B. Prabhakar Reddy, Srinivasa Rao konijeti, K. Ashok Kumar
Keywords
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