FORMULATION AND EVALUATION OF MICROEMULSION GEL FOR TRANSDERMAL DELIVERY OF TRAMADOL
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 5
Abstract
Objective: The present work was carried out to design microemulsion gel system for transdermal delivery of the drug to minimize the side effects and to reduce the frequency of administration and for prolonging the duration of action. Methods: Tramadol, an opioid analgesic drug, was mixed with various selected polymers such as sodium alginate (SA), acacia, hydroxypropyl methylcellulose (HPMC), and Eudragit in geometric mixing ratios. The drug, polymer, and other excipients were mixed thoroughly by trituration method and different formulations (F1-F8) were prepared the same quantity of all the ingredients excepting the polymers. Results: The different formulations prepared, studied, and showed that the formulation using SA as polymeric carrier had a better effect on the evaluated parameters. The drug-SA formulation exhibited better drug-polymer compatibility, optimal viscosity (2750 cps), zeta potential (−26.1 Mv), and particle size distribution (262.8 d.nm) values. The in vitro release studies also indicated that the drug-SA formulation was of desirable release pattern, thus indicating that SA to be a better choice in formulating a transdermal delivery gel system. Conclusion: Evaluated microemulsion gel formulation F2 of tramadol with polymeric carriers SA was much stable than other carriers used. Thus, it could be concluded that the gel formulation with SA can be taken as an ideal formulation.
Authors and Affiliations
MURUGANANTHAM V , PRABAKARAN M , PASUPATHI C , PEELY LR , POOJA B
Keywords
Related Articles
- EP ID EP604751
- DOI -
- Views 145
- Downloads 0
ACTIVITY OF INDIAN TOPICAL SKIN PHARMACEUTICALS AGAINST SOME FUNGAL PATHOGENS
 Objective: The aim was to assess the in vitro antifungal activity of some locally available pharmaceutical preparations used to cure skin diseases. Mostcommonly used preparations were evaluated for dermatophytic and no...
PHYTOCHEMICAL EXTRACTIONS, QUALITATIVE ANALYSIS, AND EVALUATION OF ANTIMICROBIAL ACTIVITY IN THE LEAF AND STEM BARK OF SOLANUM PUBESCENS WILLD.
Objective: The objective of this study was to extract the phytochemicals from leaf and stem bark of Solanum pubescens, perform qualitative analysis, and evaluate antimicrobial activity of the phytochemicals against certa...
PLACKETT-BURMAN DESIGN AS A TOOL FOR SCREENING AND PROCESS OPTIMIZATION OF RIVASTIGMINE-LOADED LIPID NANOCARRIERS
Objective: Plackett–Burman experimental design is used to identify the most important factors early in the experimentation phase when complete knowledge about the system is usually unavailable. The objective of this st...
NATURAL ANTIMICROBIALS IN THE PIPELINE AND POSSIBLE SYNERGISM WITH ANTIBIOTICS TO OVERCOME MICROBIAL RESISTANCE
The unresponsive use of antibiotics led to the appearance of multiple drug-resistant bacteria strains. Studying the mechanism by which bacteria can resist antibiotics, the so called quorum sensing and biofilm formation,...
EFFECT OF GYMNEMA SYLVESTRE METHANOLIC EXTRACT ON PANCREATIC PUTRESCINE LEVELS AGAINST ALLOXAN-INDUCED DIABETIC RATS
Objective: Gymnema sylvestre, a rare herb with significant medicinal values widely used as a naturopathic treatment for diabetes. This study demonstrates the antidiabetic potential and changes in the levels of pancreatic...