Formulation and Evaluation of Ocular Insitu Hydrogels of Cefdinir
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 3
Abstract
Abstract:The present research work deals with the formulation and evaluation of in-situ gelling system based on sol-to-gel transition for ophthalmic delivery of an antibacterial agent cefdinir , to overcome the problems of poor bioavailability and therapeutic response exhibited by conventional formulations. Cefdinir an antibacterial agent preferentially used in the treatment of infections caused by streptococci, which is the main cause of bacterial conjunctivitis. So in the present study ocular insitu hydrogels of cefdinir were prepared to treat bacterial conjunctivitis. Carbopol 940 was used as the gelling agent in combination with HPMCK100M which acted as a viscosity enhancing agent. Poly vinyl alcohol was used as cross linker. The prepared formulations were evaluated for pH, viscosity, clarity, drug content, gelling capacity, Invitro drug release, Exvivo diffusion studies, antimicrobial efficacy ,ocular irritancy, The clarity, pH, and drug content of the developed formulations were found in range 6.0-6.8, , 82-95% respectively. The gel provided sustained drug release over an 6 hour period. The developed formulation can be used as an in-situ gelling vehicle to enhance ocular bioavailability and helped in the reduction in the frequency of instillation thereby resulting in better patient compliance. Keywords:In-situgelation; cefdinir; Carbopol 940; HPMC K100M, HPMCK4M, HPMC E50LV.
Authors and Affiliations
Santhi priya Nagam, Sai lakshmi Jyothirmai kala, N. Rama Rao
Keywords
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