Formulation and evaluation of OlmesartanMedoxomil solid lipid nanoparticles for solubility enhancement
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
Poor aqueous solubility is a major obstacle in the development of highly effective formulation of many drugs which affect the stability and bioavailability of drug formulation. A novel technique, solid lipid nanoparticles has been developed as a strategy to overcome poor water solubility of drugs. The reduction of drug particle to the nano-level increases the surface area and improves solubility and dissolution of drug and proportionate increase in the bioavailability of poorly water soluble drugs. OlmesartanMedoxomil, antihypertensive drug used as model drug to improve its aqueous solubility, dissolution rate & ultimately bioavailability by preparing solid lipid nanoparticles using solvent emulsification-evaporation method. The prepared solid lipid nanoparticles were characterized by SEM, FTIR, DSC and XRD. The solubility profile was compared with pureOlmesartanMedoxomiland found that more than three-fold increase in solubility of OlmesartanMedoxomil SLNs. In vitro release of OLMSLNs formulation was shown to be improved as compared to pure drug.
Authors and Affiliations
B G Waghmare, P P Karle, A P Potulwar
Keywords
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- EP ID EP394506
- DOI 10.9790/3008-1302037177
- Views 118
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