Formulation and evaluation of OlmesartanMedoxomil solid lipid nanoparticles for solubility enhancement
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
Poor aqueous solubility is a major obstacle in the development of highly effective formulation of many drugs which affect the stability and bioavailability of drug formulation. A novel technique, solid lipid nanoparticles has been developed as a strategy to overcome poor water solubility of drugs. The reduction of drug particle to the nano-level increases the surface area and improves solubility and dissolution of drug and proportionate increase in the bioavailability of poorly water soluble drugs. OlmesartanMedoxomil, antihypertensive drug used as model drug to improve its aqueous solubility, dissolution rate & ultimately bioavailability by preparing solid lipid nanoparticles using solvent emulsification-evaporation method. The prepared solid lipid nanoparticles were characterized by SEM, FTIR, DSC and XRD. The solubility profile was compared with pureOlmesartanMedoxomiland found that more than three-fold increase in solubility of OlmesartanMedoxomil SLNs. In vitro release of OLMSLNs formulation was shown to be improved as compared to pure drug.
Authors and Affiliations
B G Waghmare, P P Karle, A P Potulwar
Keywords
Related Articles
- EP ID EP394506
- DOI 10.9790/3008-1302037177
- Views 111
- Downloads 0
The revival of an ancestral galenic preparation called “Ceratum” apt to re-establish the normal viscoelasticity of dermis in perilous skin diseases like iatrogenic dyshidrosis and to treat scars after milia removal.
Scope of our research is to paving the way for a revival of a very old galenic preparation, that is nort oily or waxy, and so it cannot be baptized as ointment or unguentum. But the Trojan horse is that medical device I...
Antipseudomonal Activities of Aqueous and Methanolic Peel Extracts of Carica papaya L. (Pawpaw) Unripe Fruits
In response to the multi-drug resistance of Pseudomonas aeruginosa, the discovery of new effective agents is important in overcoming the infections resulting from the organisms. The present study assessed the antipseudom...
Résultats DeLa Trabeculoplastie Sélective sur La Baisse Pressionnelle Dans Le GPAOResults of Selective Trabeculoplasty on Pressure Reduction in POAG
Pour vérifier les résultats tonométriques de SLT dans le traitement du glaucome primaire à angle ouvert une étude rétrospective a été réalisée dans notre unité glaucome. 116yeux de 58 patients ont bénéficié de la procédu...
The Effect of Berchemia Berchemiifolia to Moderate Gastric Mucosal Bleeding Caused by the Exposure to Acute Intense Stress
To evaluate the effect to moderate gastric ulcer caused by acute intense stress, this study used an experimental animal model of gastric ulcer triggered by waterlogging stress. Experimental animal groups are divided into...
Effect of Excipients on the Release of Simvastatin from Biodegradable Polymeric Implant
The objective of the present study was to develop and evaluate a sustained release Gelatin-sodium alginate biodegradable polymeric implant containing Simvastatin, an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A (HMG...