FORMULATION AND EVALUATION OF ORAL THERMOREVESIBLE IN SITU GEL CONTAINING FLUCONAZOLE
Journal Title: Int J of Pharm Res & Analy - Year 2011, Vol 1, Issue 1
Abstract
The objective of this study was to formulate and evaluate in situ oral topical gels of Fluconazole based temperature induced systems for the treatment of oral condidiasis. Conventional oral formulations like solution, suspension, and ointments have many disadvantages which result into poor bioavailability of drug in the buccal cavity. The poor bioavailability and therapeutic response may be overcome by the use of mucoadhesive in situ gel forming systems that are applied as liquid into the buccal cavity and undergo a sol-gel transition which have good mucoadhesion with buccal mucus layers. Mucoadhesive systems were prepared by using polaxamer 188 combined with carbapol 934 to enhance the gel bio adhesion properties. Increase in the concentration of mucoadhesive agent enhanced the mucoadhesive force significantly. In vitro release of Fluconazole from the mucoadhesive system in simulated salivary fluid was influenced significantly by the properties and concentration of carbapol 934 showed to enhance bioavailability through its longer oral residence time and ability to sustain the release of the drug.
Authors and Affiliations
Maheswara Reddy C , Firoz S , Rajalakshmi. R , Ashok Kumar CK.
Keywords
Related Articles
- EP ID EP116224
- DOI -
- Views 145
- Downloads 0
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 5-{4'-[(4"-ARYL)- -3"-CYANO 2"-METHOXY PYRIDINE-6"-YL] PHENYL CARBAMIDO}-DIBENZ [b,f] AZEPINES
The titled compounds (4a-4k) have been synthesized by the condensation of 5-{4'-[(3"-aryl)-2"-Propene-1"-one]- Phenyl carbamido}-dibenz [b,f] azepines with malononitrile and Sodium methoxide. The biological activities o...
CENTRIFUGAL PARTITION CHROMATOGRAPHY: AN OVERVIEW
Centrifugal partition chromatography (CPC) is a new and unique method of liquid-liquid chromatography. CPC enables the separation of components with nearly identical partition ratios, and is performed without the aid of...
UTILIZATION OF MIXED-SOLVENCY TECHNIQUE IN SPECTROPHOTOMETRIC ANALYSIS OF CEFIXIME TRIHYDRATE TABLETS
A novel, economic, eco-friendly, accurate and reproducible method was developed for quantitative analysis of cefixime trihydrate tablets. In present investigation, aqueous blend containing 5% each of sodium citrate, glyc...
ANALYTICAL STUDY OF PROCESSING UTILITY AND SOME PHYSICO-CHEMCIAL PARAMETERS OF RAW WATER, SOFT WATER AND DEMINERALIZED WATER IN KORBA AREA
World Water & Environmental Engineering is an international water quality magazine that reaches over 10,000 water quality professionals in Central India and South India. Helmed by London-based publisher Nic Chr...
METHOD DEVELOPMENT AND VALIDATION OF OLMESARTAN, AMLODIPINE AND HYDROCHLOROTHIAZIDE IN COMBINED TABLET DOSAGE FORM
A simple, accurate, precise, economical and reproducible method was developed for simultaneous estimation of olmesartan, amlodipine and hydrochlorothiazide in bulk and its dosage form. The excipients in the c...