Formulation and Evaluation of Orodispersible Piroxicam Tablets
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 10
Abstract
The demand for mouth dissolving tablets has been growing, during the last decade, especially for geriatric and paediatric patients who have swallowing difficulties. Piroxicam is a potent anti-inflammatory drug used in treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and acute gout disease. In the present work, 5 formulations of Orodispersible tablets of Piroxicam (F1 to F4) were prepared using two different superdisintegrants namely Crospovidone and sodium starch glycolate with two concentrations (3% and 5%) and a control F5 (without superdisintegrant) by direct compression method. The final blend of the drug and excipients were evaluated for powder flow properties, bulk density, tapped density, compressibility index and hausner’s ratio. All the formulations were evaluated for thickness, weight variation, disintegration time, hardness, friability, drug content and water absorption ratio. Formulation F1 showed the lowest disintegration time and more water absorption ratio. invitro dissolution studies revealed that formulation F2 showed 93.70 % percent drug release at the end of 60 minutes. The short term stability studies for the formulations showed no significant changes in disintegration time, drug content and percentage of drug released when stored at 4[sup]0[/sup]C±2[sup]0[/sup]C , 27°C ±2°C and 45[sup]0[/sup]C±2[sup]0[/sup]C for 45 days.
Authors and Affiliations
N. Ravi Kiran , S. Palanichamy , M. Rajesh , T. Godwin Rajadhas , V. Anusha , N. Parasakthi , A. Thanga Thirupathi
Keywords
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