Formulation and Evaluation of Solid Dispersion of an AntiEpileptic Drug Carbamazepine
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 5
Abstract
Carbamazepine (CBZ), relatively water insoluble anti epileptic candidate was selected as a model drug for the study, which is BCS class II drug (low soluble and high permeable). Solid dispersions were formulated with an aim of improving aqueous solubility, oral bioavailability and the rate of dissolution of Carbamazepine using different hydrophyllic polymer like Polyethylene Glycol (PEG) 6000, Polyethylene Glycol (PEG) 4000, Polyethylene Glycol (PEG) 1500, kollidon 30, HPMC 6 cps, poloxamer 407 and povidone k 30. Binary and ternary solid dispersions were prepared by physical misxing as well as fusion method with different drug-to-polymer weight ratio. The effects of different polymers on the solubility and in-vitro dissolution behavior were investigated spectrophotometrically at 288 nm. These formulations were characterized in the solid state by Fourier Transform Infrared (FTIR) spectroscopy and Scanning Electron Microscopy (SEM). SEM study indicated CBZ was present as fine particles and entrapped in carrier matrix of PEG 6000 and poloxamer 407 solid dispersions. Fourier Transform Infrared (FTIR) spectroscopic studies showed the stability of CBZ and absence of well-defined drug-polymer interactions. It was found that only 27.06% was released within 60 minutes from active carbamazepine on the other hand the release of carbamazepine from the solid dispersion containing combined PEG 6000 and poloxamer 407 at the ratio of 1:1:1 showed the best result which was 100.12% within the same period of time. Even physical mixtures of CBZ prepared with both carriers also showed better dissolution profiles than those of pure CBZ. This can be attributed to increased wettability and dispersibility, as well as decreased crystallinity and increase in amorphous fraction of drug when they remain dispersed in polymer. In conclusions, solid dispersions could be a promising delivery of CBZ with improved oral bioavailability and immediate release profiles.
Authors and Affiliations
Sharmin Akhter, Md. Salahuddin, A. K. M. Saif Uddin2,, Marufa Marium5, Md. Bodrudoza Alam6, Saikat Barua, Prakrety Chakrabarty, Mohammad Fahim Kadir
Keywords
Related Articles
- EP ID EP386652
- DOI 10.9790/3008-1105046168
- Views 48
- Downloads 0
Nanoscale Biomaterials for 3D printing
Bio printing is an emerging tool for differentiating stem cells in 3D patterns. This technique provides the platform for regeneration of organs and tissues in a systematic manner.The use of suitable biomaterial with its...
Mosquito Species Diversity And Distribution in Three Riverine Communities in Taraba State, North-Eastern Nigeria
Mostmosquitoes are nuisance and public health problem because the females consume blood and transmit diseases. Studies were carried out between September, 2015 and August 2016 to determine the composition and abundance o...
Comparative Assessment of Extracts and Fractions of Dacryodesedulis Leaves and Stem barks From Two Locations as Sources of Antimicrobial Ingredients forSkin Care Products
Plants are rich in a wide variety of phytochemicals with antimicrobial properties. Dacryodesedulis leaves and stem barks from two locations (Uyo and Ikom) were extracted with ethanol and water. The ethanol extracts were...
Role Of Panchatikta Ksheerghrita Basti,Panchatikta Ghrita Guggul Vati And Janubasti In The Management Of Sandhigata Vata W.S. R. To Osteoarthritis .
Ageing is a process of physical, psychological and social change in multi dimensional aspects. Geriatric health care is very important because in India 3.8% of the population are older than 65 years of age. Sandhigata Va...
Germ cells and the seminiferous epithelium cycle in the wild rodent Oxymycterus rufus (Rodentia: Cricetidae)
Oxymycterus rufus is a wild rodent that inhabits one of the world hotspots known as the Atlantic Rain Forest in Brazil. Due to the lack of reproductive data regarding such species, the present study aimed to describe O....