Formulation and evaluation of sustained release tablets of Zidovudine by using hibiscus as a natural polymer
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 3
Abstract
The present work is aimed at preparing and evaluating Sustained-release (SR) matrix tablets of Zidovudine tablet using different polymers. Systematic studies were conducted using different concentration of rate releasing polymers like HPMC grades and natural polymer like Hibiscus for extending the drug release up to 24 hrs. The tablets were evaluated for preformulation studies like angle of repose, bulk density, compressibility index and physical characteristics like hardness, weight variation, friability and drug content and in-vitro studies were performed. Among all the formulations (F1-F11), it was observed that formulation- 9 has shown better dissolution profile. So Formulation-9 was found to be the best formulation when compared with other prepared formulations.
Authors and Affiliations
Ch. Michel Balaiah and K Narendra Kumar Reddy
Keywords
Related Articles
- EP ID EP33385
- DOI -
- Views 286
- Downloads 0
In-vitro callus regeneration and rhizogenesis in Diploknema butyracea: a valuable tree borne oilseed
In-vitro callus regeneration and rhizogenesis is achieved from leaf segments of mature tree of Diploknema butyracea (Roxb.) Lam. Explants sterilization was standardized using 0.1% HgCl2 for 3 minutes and NaOCl (40%) fo...
Studies of relative and specific viscosities of Aceclofenacin 70% Dioxane water mixture at different temperature
Acelofenac drug plays their own identity in the drug, pharmaceutical and medicinal sciences in last decades. Hence, the viscometric study were carried out at 70% various percentage of solvent. The result obtained durin...
FORMULATION AND E VALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD
Fast dissolving tablets were highly accepted drug delivery system. Fast dissolving tablets were dissolved/ disintegrated in the mouth within a matter of few seconds without need of water. The aim of the present study wa...
EFFECTS OF PERMEABILITY CHARACTERISTICS OF DIFFERENT POLYMETHACRYLATES ON THE PHARMACEUTICAL CHARACTERISTICS OF DILTIAZEM HCL-LOADED MICROSPHERES
Microspheres containing Diltiazem hydrochloride (DTZ Hcl) were prepared with various Polymethacrylates, with different permeability characteristics (Eudragit RSPO and Eudragit RLPO) and also with mixtures of these poly...
SIMULTANEOUS SEPARATION OF SIX FLUOROQUINOLONES USING AN ISOCRATIC HPLC SYSTEM WITH UV DETECTION: APPLICATION TO ANALYSIS OF LEVOFLOXACIN IN PHARMACEUTICAL FORMULATIONS
A simple, precise, specific, highly sensitive, an accurate and reproducible isocratic reversed phase HPLC method was developed for the separation of six fluoroquinolones and validated for determination of Levofloxacin...