FORMULATION AND EVALUTION OF ORALLY DISINTEGRATING TABLETS OF MECLIZINE HYDROCHLORIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
The objective of necessary work to develop meclizine HCl fast disintegrating tablet using different disintegrant which would disintegrate tablet rapidly in oral cavity. Nine batches of meclizine HCl orally disintegrating tablets were prepared by direct compression method using sodium starch glycolate, crosscarmellose sodium, Crospovidone as disintegrant in different concentration in order to achieve faster disintegration of tablet. The influence of the disintegrant concentration on the release of meclizine HCl was studied. The formulated batches were characterized by different physical parameters. Physical parameters of all formulated tablets were within acceptable limits. The study reveals that the formulation containing Crospovidone as disintegrant shows faster disintegration compare to others.
Authors and Affiliations
Sandip Goyani , Pranav Shah , Bhavin Vyas , D. R. Shah
TAKE SOYBEAN TO REMAIN EVERGREEN
Soybean is well-recognized for its food value because of its high protein content. Soy consumption reduces the risk of developing breast, prostate and/or colon cancer. It reduces total cholesterol, LDL and triglyceride l...
GOLD NANOPARTICLES IN BIOMEDICAL APPLICATIONS
The applications of gold nanoparticles in Biomedical field are reviewed in this paper. The physical and chemical properties of Gold nanoparticles are illustrated. In this paper we present physical, chemical, and biosynth...
PROTECTIVE ROLE OF ETHANOLIC EXTRACT OF HYBANTHUS ENNEASPERMUS ON MITOCHONDRIAL MEMBRANE Na+/K+ATPase, Ca2+ATPase AND Mg2+ATPase ACTIVITIES ON CARBON TETRACHLORIDE INDUCED OXIDATIVE STRESS IN RATS
In this present study, we evaluated the liver mitochondrial membrane ATPases activities on carbon tetrachloride induced oxidative stress in rats. Wistar strain male albino rats were divided into four groups. Group I ani...
A REVIEW ON CHIKUNGUNYA VIRUS
Mosquitoes transmit numerous arboviruses including dengue and chikungunya virus (CHIKV). Chikungunya is a re-emerging arthropod-borne viral disease caused by Chikungunya virus (CHIKV) belonging to the Togaviridae family...
ANTI INFLAMMATORY, ANALGESIC AND PHYTOCHEMICAL STUDIES OF CLITORIA TERNATEA LINN FLOWER EXTRACT
Clitoria ternatea Linn is a well known bio active plant in the Ayurvedic medicine. The present study evaluates the analgesic and anti-inflammatory activity of Clitoria ternatea Linn flower extract. The petroleum ether (...