PROTECTIVE ROLE OF ETHANOLIC EXTRACT OF HYBANTHUS ENNEASPERMUS ON MITOCHONDRIAL MEMBRANE Na+/K+ATPase, Ca2+ATPase AND Mg2+ATPase ACTIVITIES ON CARBON TETRACHLORIDE INDUCED OXIDATIVE STRESS IN RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 7
Abstract
In this present study, we evaluated the liver mitochondrial membrane ATPases activities on carbon tetrachloride induced oxidative stress in rats. Wistar strain male albino rats were divided into four groups. Group I animals were served as normal and group II was administrated with corn oil as vehicle control. Group III was given single dose (29th day) of CCl4 in corn oil (1:1 v/v, 3ml/kg, i.p.). Groups IV was treated with ethanolic extract of Hybanthus enneaspermus. (Orally at the dose of 500mg per kg body weight). In CCl4 + Hybanthus enneaspermus treated rats, Na+/K+ATPase, Ca2+ATPase and Mg2+ATPase activities were attained normally when compared with CCl4 treated rats.
Authors and Affiliations
T Anand , K Gokulakrishnan , A Kalaiselvan , S Velaven
Keywords
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