Formulation and in vitro evaluation of amlodipine besylate fast disintegrating tablet by solid dispersion technique
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 2
Abstract
Amlodipine besylate is a long-acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and Rate of absorption is often controlled by rate of dissolution. The rate of dissolution will increase by incorporating the drug in fast disintegrating dosage form. An attempt has been made for the development of rapidly disintegrating tablets of amlodipine besylate by solid dispersion technique. Six solid dispersion has been prepared in different carrier formulation ratios. Dissolution study has been done for all six solid dispersion and among them best solid dispersion has been selected and used for tablet formulation. In this study, fast disintegrating tablets were prepared by direct compression method using crospovodine, croscarmellose sodium, agar and guar gum as the super disintegrants. Effect of various superdisintegrants on disintegration behaviour of tablets was evaluated in phosphate buffer pH 0.01N HCL. All formulation were evaluated for pre-compression and post compression parameters. Wetting time of formulations containing crospovodine and agar was least and tablets showed fastest disintegration. FT-IR studies revealed that there was no physic-chemical interaction between amlodipine besylate and other excipients. Amongst all formulation, formulation F6 prepared by combination of both crospovidone and agar showed least disintegrating time, and faster dissolution of 98.04%.
Authors and Affiliations
Prakash Babu Dahal, R. Sambath Kumar, K. Jaganathan, V. Kamalakkannan, C. Kannan
Keywords
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