Formulation and in vitro evaluation of amlodipine besylate fast disintegrating tablet by solid dispersion technique
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 2
Abstract
Amlodipine besylate is a long-acting calcium channel blocker used to treat chronic stable angina, vasospastic angina and hypertension. Amlodipine is a sparingly soluble orally administered drug and Rate of absorption is often controlled by rate of dissolution. The rate of dissolution will increase by incorporating the drug in fast disintegrating dosage form. An attempt has been made for the development of rapidly disintegrating tablets of amlodipine besylate by solid dispersion technique. Six solid dispersion has been prepared in different carrier formulation ratios. Dissolution study has been done for all six solid dispersion and among them best solid dispersion has been selected and used for tablet formulation. In this study, fast disintegrating tablets were prepared by direct compression method using crospovodine, croscarmellose sodium, agar and guar gum as the super disintegrants. Effect of various superdisintegrants on disintegration behaviour of tablets was evaluated in phosphate buffer pH 0.01N HCL. All formulation were evaluated for pre-compression and post compression parameters. Wetting time of formulations containing crospovodine and agar was least and tablets showed fastest disintegration. FT-IR studies revealed that there was no physic-chemical interaction between amlodipine besylate and other excipients. Amongst all formulation, formulation F6 prepared by combination of both crospovidone and agar showed least disintegrating time, and faster dissolution of 98.04%.
Authors and Affiliations
Prakash Babu Dahal, R. Sambath Kumar, K. Jaganathan, V. Kamalakkannan, C. Kannan
Keywords
Related Articles
- EP ID EP33195
- DOI -
- Views 300
- Downloads 0
INVESTIGATION OF IN-VITRO ANTI-OXIDANT, ANTI-INFLAMMATORY AND ANTI-ARTHRITIC ACTIVITY OF AERIAL PARTS OF SECURINEGA LEUCOPYRUS (WILLD.) MUELL
Securinega leucopyrus (willd.) Muell. (Euphorbiaceae) is a thorny, large shrub or small tree. In Ayurveda it has a lot of potential medicinal uses. The decoction of leaves are used to dress the cancerous wounds. The ju...
Phytochemical profile of three selected plants of Phyllanthus niruri, Psidium guajava and Punica granatum
A Photochemical profile of three selected plant species Phylanthus niruri, Psidium guajava, Punica granatum were carried out. Crude dry powder analysis ,ash value ,solubility ,extractive value ,fluorescence analysis, q...
Development and Validation of Related Substances Method for Febuxostat Tablets by RP-HPLC
The present paper describes about highly sensitive, linear, precise, rugged, accurate and robust RP-HPLC method for determination of related substances present in Febuxostat tablets. Chromatographic separation with sep...
Method development and validation of Pioglitazone and Saxagliptin by RPHPLC
Analytical method by using RP-HPLC was developed for the determination of saxagliptin and pioglitazone. Potassium dihydrogen phosphate buffer : methanol (80:20 v/v) was used as mobile phase. The detection wavelength wa...
A Study on prescribing and cost pattern of antimicrobial agents in a tertiary care teaching hospital
Now-a-days many drugs are showing resistance followed by ineffective treatment. It has become a major obstacle in treatment. Among many drugs antimicrobials drugs are also highly resistance, Anti-Microbial Resistance (...